Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65.
AuthorsJin M, Yuan Q, Li S, Travis GH,
JournalJ Biol Chem
PubMed ID17504753
Absorption of a photon by a vertebrate opsin pigment induces 11-cis to all-trans isomerization of its retinaldehyde chromophore. Restoration of light sensitivity to the bleached opsin requires chemical re-isomerization of the chromophore via an enzyme pathway called the visual cycle. The retinoid isomerase in this pathway is Rpe65, a membrane-associated ... More