Regulation of the Farnesoid X Receptor (FXR) by Bile Acid Flux in Rabbits.
Authors Xu Guorong; Pan Lu-Xing; Li Hai; Forman Barry M.; Erickson Sandra K.; Shefer Sarah; Bollineni Jaya; Batta Ashok K.; Christie Jennifer; Wang Tsu-Hong; Michel John; Yang Steve; Tsai Richard; Lai Lily; Shimada Kohei; Tint G. Stephen; Salen Gerald;
JournalJ Biol Chem
PubMed ID12401785
'We investigated the roles of hydrophobic deoxycholic acid (DCA) and hydrophilic ursocholic acid (UCA) in the regulation of the orphan nuclear farnesoid X receptor (FXR) in vivo. Rabbits with bile fistula drainage (removal of the endogenous bile acid pool), rabbits with bile fistula drainage and replacement with either DCA or ... More