Role of reduced folate carrier in intestinal folate uptake.
AuthorsBalamurugan K, Said HM,
JournalAm J Physiol Cell Physiol
PubMed ID16495369
'Studies from our laboratory and others have characterized different aspects of the intestinal folate uptake process and have shown that the reduced folate carrier (RFC) is expressed in the gut and plays a role in the uptake process. Little, however, is known about the actual contribution of the RFC system ... More
p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint.
AuthorsStauffer D, Chang B, Huang J, Dunn A, Thayer M,
JournalJ Biol Chem
PubMed ID17272271
'The highly related acetyltransferases, p300 and CREB-binding protein (CBP) are coactivators of signal-responsive transcriptional activation. In addition, recent evidence suggests that p300/CBP also interacts directly with complexes that mediate DNA replication and repair. In this report, we show that loss of p300/CBP in mammalian cells results in a defect in ... More