Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics.
AuthorsMcLaughlin J, Cheng D, Singer O, Lukacs RU, Radu CG, Verma IM, Witte ON,
JournalProc Natl Acad Sci U S A
PubMed ID18079287
'Many cancers and leukemias are associated with strong dominant oncogenic mutations that activate tyrosine kinases and other classes of molecules, including transcription factors and antiapoptotic mechanisms. Some of these events can be targeted with small molecules or antibody-based therapeutics, but many remain intractable. In addition, cancer-related enzyme targets can often ... More
Stroma-dependent apoptosis in clonal hematopoietic precursors correlates with expression of PYCARD.
The role of the marrow microenvironment in the pathophysiology of myelodysplastic syndromes (MDSs) remains controversial. Using stromal/hematopoietic cell cocultures, we investigated the effects of stroma-derived signals on apoptosis sensitivity in hematopoietic precursors. The leukemia-derived cell line KG1a is resistant to proapoptotic ligands. However, when cocultured with the human stromal cell ... More