Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe.
AuthorsNiida H, Tsuge S, Katsuno Y, Konishi A, Takeda N, Nakanishi M,
JournalJ Biol Chem
PubMed ID16159883
Mitotic catastrophe occurs as a result of the uncoupling of the onset of mitosis from the completion of DNA replication, but precisely how the ensuing lethality is regulated or what signals are involved is largely unknown. We demonstrate here the essential role of the ATM/ATR-p53 pathway in mitotic catastrophe from ... More