RNAi techniques hold great promise for science,
from basic research all the way to human therapeutics,
and our understanding of the underlying
mechanisms have allowed us to design
better and more effective compounds. Fortunately,
much has also been learned about nonspecific
effects, such as off-target and stress
responses. These observations and discoveries
have led us to improved specificity ... More
Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.
AuthorsGuan HP, Ishizuka T, Chui PC, Lehrke M, Lazar MA,
JournalGenes Dev
PubMed ID15681609
Peroxisome proliferator-activated receptor gamma (PPARgamma) is the master regulator of adipogenesis as well as the target of thiazolidinedione (TZD) antidiabetic drugs. Many PPARgamma target genes are induced during adipogenesis, but others, such as glycerol kinase (GyK), are expressed at low levels in adipocytes and dramatically up-regulated by TZDs. Here, we ... More