RIP140-targeted repression of gene expression in adipocytes.
AuthorsChristian M, Kiskinis E, Debevec D, Leonardsson G, White R, Parker MG,
JournalMol Cell Biol
PubMed ID16227589
'Ligand-dependent repression of nuclear receptor activity forms a novel mechanism for regulating gene expression. To investigate the intrinsic role of the corepressor RIP140, we have monitored gene expression profiles in cells that express or lack the RIP140 gene and that can be induced to undergo adipogenesis in vitro. In contrast ... More
Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3.
The endothelial cell (EC)-derived tissue inhibitor of metalloproteinase-2 (TIMP-2) and pericyte-derived TIMP-3 are shown to coregulate human capillary tube stabilization following EC-pericyte interactions through a combined ability to block EC tube morphogenesis and regression in three-dimensional collagen matrices. EC-pericyte interactions strongly induce TIMP-3 expression by pericytes, whereas ECs produce TIMP-2 ... More