P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.
AuthorsWang KC, Kim JA, Sivasankaran R, Segal R, He Z,
JournalNature
PubMed ID12422217
In inhibiting neurite outgrowth, several myelin components, including the extracellular domain of Nogo-A (Nogo-66), oligodendrocyte myelin glycoprotein (OMgp) and myelin-associated glycoprotein (MAG), exert their effects through the same Nogo receptor (NgR). The glycosyl phosphatidylinositol (GPI)-anchored nature of NgR indicates the requirement for additional transmembrane protein(s) to transduce the inhibitory signals ... More