DREAM is a Ca2+-regulated transcriptional repressor.
AuthorsCarrion AM, Link WA, Ledo F, Mellstrom B, Naranjo JR
JournalNature
PubMed ID10078534
Fluxes in amounts of intracellular calcium ions are important determinants of gene expression. So far, Ca2+-regulated kinases and phosphatases have been implicated in changing the phosphorylation status of key transcription factors and thereby modulating their function. In addition, direct effectors of Ca2+-induced gene expression have been suggested to exist in ... More
Regulation of AUF1 expression via conserved alternatively spliced elements in the 3' untranslated region.
AuthorsWilson GM, Sun Y, Sellers J, Lu H, Penkar N, Dillard G, Brewer G
JournalMol Cell Biol
PubMed ID10330146
The A+U-rich RNA-binding factor AUF1 exhibits characteristics of a trans-acting factor contributing to the rapid turnover of many cellular mRNAs. Structural mapping of the AUF1 gene and its transcribed mRNA has revealed alternative splicing events within the 3' untranslated region (3'-UTR). In K562 erythroleukemia cells, we have identified four alternatively ... More
Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis
AuthorsStrezoska Z, Pestov DG, Lau LF
JournalMol Cell Biol
PubMed ID10891491
We have identified and characterized a novel mouse protein, Bop1, which contains WD40 repeats and is highly conserved through evolution. bop1 is ubiquitously expressed in all mouse tissues examined and is upregulated during mid-G(1) in serum-stimulated fibroblasts. Immunofluorescence analysis shows that Bop1 is localized predominantly to the nucleolus. In sucrose ... More
Structure and ligand of a histone acetyltransferase bromodomain.
AuthorsDhalluin C, Carlson JE, Zeng L, He C, Aggarwal AK, Zhou MM
JournalNature
PubMed ID10365964
Histone acetylation is important in chromatin remodelling and gene activation. Nearly all known histone-acetyltransferase (HAT)-associated transcriptional co-activators contain bromodomains, which are approximately 110-amino-acid modules found in many chromatin-associated proteins. Despite the wide occurrence of these bromodomains, their three-dimensional structure and binding partners remain unknown. Here we report the solution structure ... More