Stable plasma membrane levels of hCTR1 mediate cellular copper uptake.
AuthorsEisses JF, Chi Y, Kaplan JH,
JournalJ Biol Chem
PubMed ID15634665
The human copper transporter 1 (hCtr1), when heterologously overexpressed in insect cells, mediates saturable Cu uptake. In mammalian expression systems, a rapid Cu-dependent internalization of hCtr1 has been reported in cells that overexpress epitope-tagged hCtr1 when exposed to Cu in the external medium. This finding led to the suggestion that ... More
The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the integrin alpha4beta1.
Authors Bridges Lance C; Tani Patricia H; Hanson Krista R; Roberts Charles M; Judkins Matthew B; Bowditch Ron D;
JournalJ Biol Chem
PubMed ID11724793
The interaction of lymphocytes with other cells is critical for normal immune surveillance and response. MDC-L (ADAM 28), a member of the ADAM (a disintegrin and metalloprotease) protein family, is expressed on the surface of human lymphocytes. ADAMs possess a disintegrin-like domain similar in sequence to small non-enzymatic snake venom ... More