Transforming growth factor-beta and interleukin-10 in breast milk and development of atopic diseases in infants.
AuthorsRigotti E, Piacentini GL, Ress M, Pigozzi R, Boner AL, Peroni DG,
JournalClin Exp Allergy
PubMed ID16650046
'Precise relationship between breastfeeding and infant allergy is poorly understood. Objective Aim was to quantify TGF-beta(1) and IL-10 in colostrum and mature milk from allergic and non-allergic mothers and to verify relationship with allergic disease development. Mothers (13 allergics, nine controls) of 22 newborns participated to prospective study on development ... More
Interleukin-10-independent anti-inflammatory actions of glucagon-like peptide 2.
AuthorsIvory CP, Wallace LE, McCafferty DM, Sigalet DL,
JournalAm J Physiol Gastrointest Liver Physiol
PubMed ID18845573
'Glucagon-like peptide 2 (GLP-2) is an important intestinal growth factor with anti-inflammatory activity. We hypothesized that GLP-2 decreases mucosal inflammation and the associated increased epithelial proliferation by downregulation of Th1 cytokines attributable to reprogramming of lamina propria immune regulatory cells via an interleukin-10 (IL-10)-independent pathway. The effects of GLP-2 treatment ... More
Preservation of tear film integrity and inhibition of corneal injury by dexamethasone in a rabbit model of lacrimal gland inflammation-induced dry eye.
AuthorsNagelhout TJ, Gamache DA, Roberts L, Brady MT, Yanni JM,
JournalJ Ocul Pharmacol Ther
PubMed ID15857280
'The aim of this study was to establish a clinically relevant short-term animal model of dry eye with utility in identifying compounds with potential therapeutic efficacy. Rabbit lacrimal glands were injected with the T-cell mitogen Concanavalin A (Con A) and inflammation, tear function, and corneal epithelial cell integrity were subsequently ... More
The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation.
AuthorsYanik GA, Ho VT, Levine JE, White ES, Braun T, Antin JH, Whitfield J, Custer J, Jones D, Ferrara JL, Cooke KR,
JournalBlood
PubMed ID18664626
'Idiopathic pneumonia syndrome (IPS) refers to a diffuse, noninfectious, acute lung injury after hematopoietic stem cell transplantation. Historically, IPS is associated with respiratory failure and mortality rates exceeding 50%. Preclinical studies have implicated tumor necrosis factor-alpha as an important effector molecule in the development of disease. We studied the tumor ... More
Clinicopathological variables predicting progression of azotemia in cats with chronic kidney disease.
AuthorsChakrabarti S, Syme HM, Elliott J,
JournalJ Vet Intern Med
PubMed ID22269057
'Chronic kidney disease (CKD) is common in geriatric cats, but often appears to be stable for long periods of time. To describe CKD progression and identify risk factors for progression in newly diagnosed azotemic cats. A total of 213 cats with CKD (plasma creatinine concentration > 2 mg/dL, urine specific ... More
PGE2 induces angiogenesis via MT1-MMP-mediated activation of the TGFbeta/Alk5 signaling pathway.
AuthorsAlfranca A, López-Oliva JM, Genís L, López-Maderuelo D, Mirones I, Salvado D, Quesada AJ, Arroyo AG, Redondo JM,
JournalBlood
PubMed ID18541723
'The development of a new vascular network is essential for the onset and progression of many pathophysiologic processes. Cyclooxygenase-2 displays a proangiogenic activity in in vitro and in vivo models, mediated principally through its metabolite prostaglandin E(2) (PGE(2)). Here, we provide evidence for a novel signaling route through which PGE(2) ... More
Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos.
AuthorsMurray AR, Kisin ER, Tkach AV, Yanamala N, Mercer R, Young SH, Fadeel B, Kagan VE, Shvedova AA,
JournalPart Fibre Toxicol
PubMed ID22490147
'Carbon nanotubes (CNT) and carbon nanofibers (CNF) are allotropes of carbon featuring fibrous morphology. The dimensions and high aspect ratio of CNT and CNF have prompted the comparison with naturally occurring asbestos fibers which are known to be extremely pathogenic. While the toxicity and hazardous outcomes elicited by airborne exposure ... More
Letter of retraction: Suppression of discoidin domain receptor 1 by RNA interference attenuates lung inflammation.
AuthorsWatanabe M, Shirahama Y, Hirano R, Mitsuyama H, Higashimoto I, Osame M, Arimura K
JournalJ Immunol
PubMed ID18941259
Effects of amniotic and maternal CD-146, TGF-ß1, IL-12, IL-18 and IFN-?, on adverse pregnancy outcome.
AuthorsCift T, Uludag S, Aydin Y, Benian A
JournalJ Matern Fetal Neonatal Med
PubMed ID22913276
Our aim was to determine the effects of maternal serum and amniotic fluid levels of cluster of differentiation 146 (CD-146), transforming growth factor (TGF)-ß1, interleukin (IL)-12, IL-18, and interferon (IFN)-? on intrauterine growth restriction and preterm labor. ... More
Matrix metalloproteinase-9, transforming growth factor-ß1, and tumor necrosis factor-a plasma levels in chronic pancreatitis.
AuthorsManjari KS, Jyothy A, Vidyasagar A, Prabhakar B, Nallari P, Venkateshwari A
JournalIndian J Gastroenterol
PubMed ID23408257
The aim of the study was to investigate the plasma levels of matrix metalloproteinase-9 (MMP-9), transforming growth factor-ß 1 (TGF-ß1), and tumor necrosis factor-a (TNF-a) in chronic pancreatitis (CP). ... More
Urinary transforming growth factor-beta1 in feline chronic renal failure.
AuthorsArata S, Ohmi A, Mizukoshi F, Baba K, Ohno K, Setoguchi A, Tsujimoto H,
JournalJ Vet Med Sci
PubMed ID16397385
Transforming growth factor-beta1 (TGF-beta1), an inflammatory cytokine, plays a role in tissue fibrosis, such as glomerular sclerosis and tubulointerstitial fibrosis of the kidneys. In the present study, the urinary TGF-beta1 level of cats diagnosed with chronic renal failure (CRF) was measured to investigate its relationship to the pathogenesis of feline ... More
In vivo chondrocyte and transforming growth factor-ß1 delivery using the thermosensitive chitosan/starch/ß-glycerol phosphate hydrogel.
AuthorsFaikrua A, Wittaya-Areekul S, Oonkhanond B, Viyoch J,
JournalJ Biomater Appl
PubMed ID22457042
In present study, the chitosan/starch/ß-glycerol phosphate hydrogel was investigated as an effective carrier for chondrocytes and delivery of transforming growth factor-ß1. In vitro study indicated that transforming growth factor-ß1 was released sustainably for 14 days with its biological activity to stimulate chondrocyte functions, as indicated by the strong expression of type ... More
Urinary cytokine levels in apparently healthy cats and cats with chronic kidney disease.
Chronic kidney disease (CKD) is a common cause of illness and death in cats. The hallmark of CKD in cats is chronic tubulointerstitial nephritis, and inflammation contributes to the progression of renal fibrosis. However, at present, it is difficult to assess directly the degree of intra-renal inflammation without renal biopsy. ... More
Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model.
AuthorsKuramoto E, Nishiuma T, Kobayashi K, Yamamoto M, Kono Y, Funada Y, Kotani Y, Sisson TH, Simon RH, Nishimura Y,
JournalAm J Physiol Lung Cell Mol Physiol
PubMed ID19098125
The airway remodeling that occurs in asthma is characterized by an excess of extracellular matrix deposition in the submucosa, hyperplasia/hypertrophy of smooth muscle, goblet cell metaplasia, and accumulation of fibroblasts/myofibroblasts. The urokinase-type plasminogen activator (uPA)/plasmin system participates in pericellular proteolysis and is capable of directly degrading matrix components, activating latent ... More
Advanced oxidation protein products induce mesangial cell perturbation through PKC-dependent activation of NADPH oxidase.
AuthorsWei XF, Zhou QG, Hou FF, Liu BY, Liang M,
JournalAm J Physiol Renal Physiol
PubMed ID19019916
Mesangial deposition of extracellular matrix (ECM) is a hallmark of several glomerular diseases including diabetic nephropathy. Accumulation of advanced oxidation protein products (AOPPs) has been found in diabetes and chronic kidney disease and linked to mesangial ECM deposition and progressive glomerulosclerosis in these disorders. Although emerging evidence implicates AOPPs as ... More
Immune regulatory cytokines in the milk of lactating women from farming and urban environments.
AuthorsPeroni DG, Pescollderungg L, Piacentini GL, Rigotti E, Maselli M, Watschinger K, Piazza M, Pigozzi R, Boner AL,
JournalPediatr Allergy Immunol
PubMed ID20718928
Children living on farms have fewer allergies. It is unclear whether breastfeeding in different environments contributes to preventing allergies by exposing offspring to different cytokines that can modulate immune responses. The aim of this study was to quantify and compare levels of Transforming Growth Factor-beta1 (TGF-beta1) and Interleukin-10 (IL-10) in ... More
Identification of the peripheral blood levels of interleukin-12, interleukin-10, and transforming growth factor-ß in patients with laryngeal squamous cell carcinoma.
AuthorsGünaydin RÖ, Kesikli SA, Kansu E, Hosal AS,
JournalHead Neck
PubMed ID21472884
The aim of this study was to investigate the biology of laryngeal squamous cell carcinoma (SCC) to develop effective novel treatment modalities. Serum concentrations of interleukin (IL)-10, IL-12, and transforming growth factor-ß (TGF-ß) were evaluated in 50 patients with laryngeal SCC and 15 controls. Results were compared according to tumor-node-metastasis ... More
Anti-inflammatory and anti-fibrotic effects of sirolimus on bleomycin-induced pulmonary fibrosis in rats.
AuthorsTulek B, Kiyan E, Toy H, Kiyici A, Narin C, Suerdem M,
JournalClin Invest Med
PubMed ID22129924
Pulmonary fibrosis is a devastating disease with a poor prognosis. Although the diagnosis and pathophysiology of this disease have been better characterized over the past few years, there is no effective therapy for the disease. The aim of this study was to evaluate the anti-inflammatory and anti-fibrotic effects of sirolimus ... More
Carcinoembryonic antigen-specific but not antiviral CD4+ T cell immunity is impaired in pancreatic carcinoma patients.
AuthorsTassi E, Gavazzi F, Albarello L, Senyukov V, Longhi R, Dellabona P, Doglioni C, Braga M, Di Carlo V, Protti MP,
JournalJ Immunol
PubMed ID18941250
Pancreatic carcinoma is a very aggressive disease with dismal prognosis. Although evidences for tumor-specific T cell immunity exist, factors related to tumor microenvironment and the presence of immunosuppressive cytokines in patients' sera have been related to its aggressive behavior. Carcinoembryonic Ag (CEA) is overexpressed in 80-90% of pancreatic carcinomas and ... More
Outer membrane protein A expression in Escherichia coli K1 is required to prevent the maturation of myeloid dendritic cells and the induction of IL-10 and TGF-beta.
AuthorsMittal R, Prasadarao NV,
JournalJ Immunol
PubMed ID18684958
Dendritic cells (DCs) are professional APCs that direct both cellular and humoral immune responses. Escherichia coli K1 causes meningitis in neonates; however, the interactions between this pathogen and DCs have not been previously explored. In the present study, we observed that E. coli K1, expressing outer membrane protein A (OmpA), ... More
Characterization of the secretome of human tooth germ stem cells (hTGSCs) reveals neuro-protection by fine-tuning micro-environment.
AuthorsYalvaç ME, Yarat A, Mercan D, Rizvanov AA, Palotás A, Sahin F
JournalBrain Behav Immun
PubMed ID23517709
Bone-marrow-derived mesenchymal stem cells (MSCs) demonstrate neuro-protective effects in several disease models. By producing growth-factors, cytokines and chemokines, they promote survival of neurons in damaged brain areas. Alternative MSC sources, such as human tooth germ stem cells (hTGSCs), have been investigated for their neuro-protective properties. They ameliorate effects of neuro-toxic ... More
Effect of fiber length on carbon nanotube-induced fibrogenesis.
AuthorsManke A, Luanpitpong S, Dong C, Wang L, He X, Battelli L, Derk R, Stueckle TA, Porter DW, Sager T, Gou H, Dinu CZ, Wu N, Mercer RR, Rojanasakul Y
Journal
PubMed ID24786100
Given their extremely small size and light weight, carbon nanotubes (CNTs) can be readily inhaled by human lungs resulting in increased rates of pulmonary disorders, particularly fibrosis. Although the fibrogenic potential of CNTs is well established, there is a lack of consensus regarding the contribution of physicochemical attributes of CNTs ... More
Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells.
AuthorsAoki H, Ohnishi H, Hama K, Ishijima T, Satoh Y, Hanatsuka K, Ohashi A, Wada S, Miyata T, Kita H, Yamamoto H, Osawa H, Sato K, Tamada K, Yasuda H, Mashima H, Sugano K
JournalAm J Physiol Cell Physiol
PubMed ID16371439
Pancreatic stellate cells (PSCs) are activated during pancreatitis and promote pancreatic fibrosis by producing and secreting ECMs such as collagen and fibronectin. IL-1beta has been assumed to participate in pancreatic fibrosis by activating PSCs. Activated PSCs secrete various cytokines that regulate PSC function. In this study, we have examined IL-1beta ... More
Limbal Fibroblasts Maintain Normal Phenotype in 3D RAFT Tissue Equivalents Suggesting Potential for Safe Clinical Use in Treatment of Ocular Surface Failure.
AuthorsMassie I, Dale SB, Daniels JT
Journal
PubMed ID25380529
Limbal epithelial stem cell deficiency can cause blindness, but transplantation of these cells on a carrier such as human amniotic membrane can restore vision. Unfortunately, clinical graft manufacture using amnion can be inconsistent. Therefore, we have developed an alternative substrate, Real Architecture for 3D Tissue (RAFT), which supports human limbal ... More
Polyunsaturated fatty acids modify expression of TGF-ß in a co-culture model ultilising human colorectal cells and human peripheral blood mononuclear cells exposed to Lactobacillus gasseri, Escherichia coli and Staphylococcus aureus.
AuthorsBentley-Hewitt KL, De Guzman CE, Ansell J, Mandimika T, Narbad A, Lund EK
Journal
PubMed ID25598698
Commensal bacteria and polyunsaturated fatty acids (PUFAs) have both been shown independently to modulate immune responses. This study tested the hypothesis that the different colonic immunomodulatory responses to commensal (Lactobacillus gasseri) and pathogenic bacteria (Escherichia coli and Staphylococcus aureus) may be modified by PUFAs. Experiments used a Transwell system combining ... More
Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: The importance of microglia phenotype.
AuthorsMarshall SA, McClain JA, Kelso ML, Hopkins DM, Pauly JR, Nixon K
JournalNeurobiol Dis
PubMed ID23313316
Excessive alcohol intake, a defining characteristic of an alcohol use disorder (AUD), results in neurodegeneration in the hippocampus and entorhinal cortex that has been linked to a variety of cognitive deficits. Neuroinflammation is thought to be a factor in alcohol-induced neurodegeneration, and microglia activation is a key but not sole ... More