Human CD4+CD25+ regulatory T cells suppress anti-porcine xenogeneic responses.
AuthorsPorter CM, Bloom ET
JournalAm J Transplant
PubMed ID15996259
Due to the shortage of human organs, xenotransplantation is being explored as an alternative to allotransplantation, but immune rejection remains a major hurdle to its implementation. We tested the ability of human CD4+CD25+ T cells (Treg cells) to suppress CD4+ T cell-mediated anti-porcine xenoresponses usingin vitroassays. Human Treg cells were ... More