Deletion of the eIF2a Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease.
AuthorsDevi L, Ohno M
Journal
PubMed ID24146979
'Emerging evidence suggests that dysregulated translation through phosphorylation of eukaryotic initiation factor-2a (eIF2a) may contribute to Alzheimer''s disease (AD) and related memory impairments. However, the underlying mechanisms remain unclear. Here, we crossed knockout mice for an eIF2a kinase (GCN2: general control nonderepressible-2 kinase) with 5XFAD transgenic mice, and investigated whether ... More