Cytokine production in varicella-zoster virus-stimulated cultures of human blood lymphocytes.
AuthorsHayward AR, Cosyns M, Jones M, Levin MJ, Villanueba E, Weinberg A, Chan CY,
JournalJ Infect Dis
PubMed ID9852984
'Estimates of responder cell frequency (RCF) based on limiting dilution analyses are laborious, and alternative means to quantitate cell-mediated immunity to immunogens are desirable. It was shown that levels of interleukin (IL)-2 in the supernatant of varicella-zoster virus-stimulated blood lymphocytes from immune adults peaked at 48 h of culture and ... More
In vitro immunomodulatory activity of ruthenium complexes.
AuthorsNewcomb JR, Rivnay B, Bastos CM, Ocain TD, Gordon K, Gregory P, Turci SM, Sterne KA, Jesson M, Krieger J, Jenson JC, Jones B,
JournalInflamm Res
PubMed ID12835898
We have explored the in vitro immunomodulatory effects of pure ruthenium red and a series of pyridine and imidazole substituted ruthenium complexes (RCs). Human peripheral blood lymphocytes and purified T cells were used in these studies along with various cell lines. Cells were treated with dilutions of RCs and assessed ... More