Effects of glucan treatment on the Th1/Th2 balance in patients with allergic rhinitis: a double-blind placebo-controlled study.
AuthorsKirmaz C, Bayrak P, Yilmaz O, Yuksel H,
JournalEur Cytokine Netw
PubMed ID15941684
'Allergic rhinitis (AR) is a disease characterized by IgE-mediated, allergic inflammation of the nasal mucosa. T helper (Th) 2 cells play an important role in the development of IgE-mediated diseases such as AR, with local overproduction of Th2 cytokines (IL-4, IL-5 and IL-13) at the site of allergic inflammation. Th1 ... More
Sustained immunological effects of Glatiramer acetate in patients with multiple sclerosis treated for over 6 years.
AuthorsChen M, Conway K, Johnson KP, Martin R, Dhib-Jalbut S,
JournalJ Neurol Sci
PubMed ID12163197
'The availability of a group of multiple sclerosis (MS) patients at the University of Maryland, who had participated in the pivotal Copaxone trial in the early 1990s, provided an opportunity to examine the long-term immunologic effects of Glatiramer acetate (GA) treatment in MS. Forty-eight GA-reactive T-cell lines (TCL) were generated ... More
Augmentation in expression of activation-induced genes differentiates memory from naive CD4+ T cells and is a molecular mechanism for enhanced cellular response of memory CD4+ T cells.
AuthorsLiu K, Li Y, Prabhu V, Young L, Becker KG, Munson PJ, Weng Np
JournalJ Immunol
PubMed ID11390484
'In an attempt to understand the molecular basis for the immunological memory response, we have used cDNA microarrays to measure gene expression of human memory and naive CD4+ T cells at rest and after activation. Our analysis of 54,768 cDNA clones provides the first glimpse into gene expression patterns of ... More
Bullous pemphigoid: interaction of interleukin 5, anti-basement membrane zone antibodies and eosinophils. A preliminary observation. .
AuthorsEngineer L, Bhol K, Kumari S, Razzaque Ahmed A,
JournalCytokine
PubMed ID11145840
'Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the presence of autoantibodies to normal components of the hemidesmosome (BPAg1 and BPAg2). Histology of skin lesions demonstrate a subepidermal vesicle and a predominantly eosinophilic dermal cellular infiltrate. Interleukin 5 (IL-5) plays a major role in eosinophil recruitment and ... More
Induction of type 2 activity in adult human CD8(+) T cells by repeated stimulation and IL-4.
AuthorsStanciu LA, Roberts K, Lau LC, Coyle AJ, Johnston SL,
JournalInt Immunol
PubMed ID11222503
'Repeated administration or chronic presence of antigen during CD4(+) T cell activation and a cytokine milieu enriched in IL-4 favour the generation and maintenance of a T(h)2 population. However, there is little data on how these factors affect adult human CD8(+) T cell functions. We established in vitro conditions to ... More
Bystander modulation of chemokine receptor expression on peripheral blood T lymphocytes mediated by glatiramer therapy.
AuthorsAllie R, Hu L, Mullen KM, Dhib-Jalbut S, Calabresi PA,
JournalArch Neurol
PubMed ID15956159
Glatiramer acetate therapy is thought to be effective for multiple sclerosis (MS) by promoting T(H)2 cytokine deviation, possibly in the brain, but the exact mechanism and site of action are incompletely understood. Determining the site of action and effect of glatiramer on cell trafficking is of major importance in designing ... More
Hypothermia augments NF-kappaB activity and the production of IL-12 and IFN-gamma.
AuthorsArai T, Kaneko H, Ohnishi H, Matsui E, Fukao T, Kawamoto N, Kasahara K, Kondo N,
JournalAllergol Int
PubMed ID18690006
The differentiation of Th1 and Th2 is strictly regulated by humoral and cellular factors. The imbalance between Th1 and Th2 is considered to be the pathogenesis of allergic and autoimmune disorders. It is important to elucidate the effect of environmental factors, such as temperature, on the expression of cytokines of ... More
Tear levels of interferon-gamma, interleukin (IL) -2, IL-4 and IL-5 in patients with vernal keratoconjunctivitis, atopic keratoconjunctivitis and allergic conjunctivitis.
AuthorsUchio E, Ono SY, Ikezawa Z, Ohno S,
JournalClin Exp Allergy
PubMed ID10606937
A predominance of TH2 activity in chronic allergic diseases, such as vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC), has been suggested recently. However, there is no published study on tear levels of cytokines of the two different subgroups, TH1 and TH2, in patients with ocular allergy. We measured interferon (IFN)-gamma, ... More
Modulation of T-cell function by (R)- and (S)-isomers of albuterol: anti-inflammatory influences of (R)-isomers are negated in the presence of the (S)-isomer.
AuthorsBaramki D, Koester J, Anderson AJ, Borish L,
JournalJ Allergy Clin Immunol
PubMed ID11897990
beta(2)-Adrenergic agonists interact with specific receptors on T lymphocytes to mediate anti-inflammatory activities. However, anti-inflammatory effects are not observed when beta(2)-adrenergic agonists are administered in vivo as racemates. We hypothesized that anti-inflammatory influences are mediated by the (R)-isomer and are masked in the additional presence of the (S)-isomer. Antigen-specific T-cell ... More
Cutting edge: oral type I IFN-tau promotes a Th2 bias and enhances suppression of autoimmune encephalomyelitis by oral glatiramer acetate.
AuthorsSoos JM, Stüve O, Youssef S, Bravo M, Johnson HM, Weiner HL, Zamvil SS,
JournalJ Immunol
PubMed ID12193686
IFN-tau, a novel type I IFN that possesses immunomodulatory properties, lacks toxicity normally associated with other type I IFNs. We examined the effects of oral IFN-tau alone and in combination with oral glatiramer acetate in experimental allergic encephalomyelitis (EAE). By comparison of oral administration of IFN-alpha, -beta, and -tau to ... More
Optimization of the weck-Cel collection method for quantitation of cytokines in mucosal secretions.
AuthorsRohan LC, Edwards RP, Kelly LA, Colenello KA, Bowman FP, Crowley-Nowick PA,
JournalClin Diagn Lab Immunol
PubMed ID10618275
Measurement of immune components in mucosal secretions is important for the evaluation of local immunity at the mucosal surfaces. The Weck-Cel ophthalmic sponge provides a method for the collection of these secretions. The sponge absorbs a relatively large volume of material, therefore allowing for quantitation of multiple immune components. Additionally, ... More