Visceral adiposity index is associated with insulin sensitivity and adipocytokine levels in newly diagnosed acromegalic patients.
AuthorsCiresi A, Amato MC, Pizzolanti G, Giordano Galluzzo C,
JournalJ Clin Endocrinol Metab
PubMed ID22679062
'The visceral adiposity index (VAI) has proved to be a marker of visceral adipose dysfunction, strongly associated with insulin sensitivity in both the general and specific populations of patients at metabolic risk. The objective of the study was to test VAI as a useful tool to assess early metabolic risk ... More
Anemia in Hodgkin's lymphoma: the role of interleukin-6 and hepcidin.
Cytokines play a pivotal role in Hodgkin's lymphoma (HL). Because interleukin-6 (IL-6) induces expression of hepcidin, one of the principal regulators of iron metabolism, we studied the contribution of hepcidin in anemia in HL at diagnosis. Plasma samples from 65 patients with HL were analyzed for hepcidin levels using a ... More
B-cell stimulatory cytokines and markers of immune activation are elevated several years prior to the diagnosis of systemic AIDS-associated non-Hodgkin B-cell lymphoma.
The risk of developing non-Hodgkin lymphoma (NHL) is greatly increased in HIV infection. The aim of this study was to determine whether elevated serum levels of molecules associated with B-cell activation precede the diagnosis of AIDS-associated NHL (AIDS-NHL). Serum levels of B-cell activation-associated molecules, interleukin (IL)6, IL10, soluble CD23 (sCD23), ... More
Endotoxemia causes central downregulation of sympathetic vasomotor tone in healthy humans.
Experimental endotoxemia as a model of the initial septic response affects the autonomic nervous system with profound cardiovascular sequelae. Whether the postsynaptic sympathoneural activity to the muscle vascular bed is altered in the early septic phase remains to be determined. The present study aimed to elucidate the early effects of ... More
Estradiol and inflammatory markers in older men.
AuthorsMaggio M, Ceda GP, Lauretani F, Bandinelli S, Metter EJ, Artoni A, Gatti E, Ruggiero C, Guralnik JM, Valenti G, Ling SM, Basaria S, Ferrucci L,
JournalJ Clin Endocrinol Metab
PubMed ID19050054
BACKGROUND: Aging is characterized by a mild proinflammatory state. In older men, low testosterone levels have been associated with increasing levels of proinflammatory cytokines. It is still unclear whether estradiol (E2), which generally has biological activities complementary to testosterone, affects inflammation. METHODS: We analyzed data obtained from 399 men aged ... More
Optimization of the weck-Cel collection method for quantitation of cytokines in mucosal secretions.
AuthorsRohan LC, Edwards RP, Kelly LA, Colenello KA, Bowman FP, Crowley-Nowick PA,
JournalClin Diagn Lab Immunol
PubMed ID10618275
Measurement of immune components in mucosal secretions is important for the evaluation of local immunity at the mucosal surfaces. The Weck-Cel ophthalmic sponge provides a method for the collection of these secretions. The sponge absorbs a relatively large volume of material, therefore allowing for quantitation of multiple immune components. Additionally, ... More