Immunomodulation and adenoviral gene transfer to the lungs of nonhuman primates.
AuthorsShean MK, Baskin G, Sullivan D, Schurr J, Cavender DE, Shellito JE, Schwarzenberger PO, Kolls JK,
JournalHum Gene Ther
PubMed ID10811233
Previous data from our laboratory and others have demonstrated a critical role for the CD4+ T lymphocyte in in vivo immune responses to recombinant adenoviral vectors. In rodent models, this subset of T cells is required for T cell proliferation, subsequent cytotoxic T cell generation, and production of anti-adenoviral antibodies ... More