Differential expression of cytokines in painful and painless neuropathies.
AuthorsUçeyler N, Rogausch JP, Toyka KV, Sommer C,
JournalNeurology
PubMed ID17606879
Pain is a common symptom in peripheral neuropathies. The factors determining why some peripheral neuropathies are painful and others are not are incompletely understood. Pro-inflammatory cytokines have been implicated to play a crucial role in the generation of pain. To investigate whether cytokine profiles differ between patients with painful or ... More
IL-21 effects on human IgE production in response to IL-4 or IL-13.
AuthorsWood N, Bourque K, Donaldson DD, Collins M, Vercelli D, Goldman SJ, Kasaian MT,
JournalCell Immunol
PubMed ID15919378
'In human atopic disease, IgE sensitizes the allergic response, while IgG4 is protective. Because IL-4 and IL-13 trigger switch recombination to both IgE and IgG4, additional agents must regulate the balance between these isotypes to influence susceptibility or tolerance to atopy. In this report, we define in vitro conditions leading ... More
A menstrual cycle pattern for cytokine levels exists in HIV-positive women: implication for HIV vaginal and plasma shedding.
AuthorsAl-Harthi L, Kovacs A, Coombs RW, Reichelderfer PS, Wright DJ, Cohen MH, Cohn J, Cu-Uvin S, Watts H, Lewis S, Beckner S, Landay A,
JournalAIDS
PubMed ID11504986
'To evaluate the effect of the menstrual cycle in HIV-positive women on plasma and genital cytokine levels, interrelationships between vaginal and plasma cytokines, CD4 and CD8 T cell fluctuations, and genital and plasma viral loads. Plasma and cervicovaginal lavage specimens were collected from 55 HIV-positive women with CD4 cell counts ... More
Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescents.
AuthorsWang C, Tang J, Geisler WM, Crowley-Nowick PA, Wilson CM, Kaslow RA,
JournalJ Infect Dis
PubMed ID15747244
'Antigen presentation and immune activation are essential to the effective control of infectious diseases. In 485 North American adolescents at high risk for genital Chlamydia trachomatis infection, we found 2 human leukocyte antigen variants (DRB1*03-DQB1*04 and DQB1*06) to be associated with recurrent Chlamydia infection (adjusted relative odds [RO], >2.0; P<.01, ... More
Keratinocyte gene therapy for systemic diseases. Circulating interleukin 10 released from gene-transferred keratinocytes inhibits contact hypersensitivity at distant areas of the skin.
'This study has examined the systemic effects of a circulating gene product, human interleukin 10 (IL-10), released from transduced keratinocytes. IL-10 is an anti-inflammatory cytokine which has an inhibitory effect on contact hypersensitivity (CHS). An expression vector (phIL-10) was constructed for human IL-10 and was injected into the dorsal skin ... More
Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production.
AuthorsEigler A, Siegmund B, Emmerich U, Baumann KH, Hartmann G, Endres S,
JournalJ Leukoc Biol
PubMed ID9469479
'Interleukin-10 (IL-10) and tumor necrosis factor (TNF) exert key roles in some acute and chronic inflammatory diseases. In this study we investigated (1) the potency of different cAMP-elevating agents in enhancing IL-10 synthesis, (2) the involvement of protein kinase A in this enhancement, and (3) the mutual dependence of cAMP-enhanced ... More
Bovine dialyzable leukocyte extract modulates cytokines and nitric oxide production in lipopolysaccharide-stimulated human blood cells.
AuthorsFranco-Molina MA, Mendoza-Gamboa E, Castillo-Tello P, Isaza-Brando CE, García ME, Castillo-León L, Tamez-Guerra RS, Rodríguez-Padilla C,
JournalCytotherapy
PubMed ID17573613
In the current study, we determined whether bovine dialyzable leukocyte extract (bDLE) modulates lipopolysaccharide (LPS)-induced nitric oxide and cytokine overproduction. Human whole blood cells were treated with LPS (50 ng) + bDLE (1 U). The bDLE treatment decreased nitric oxide as well as TNF-alpha, IL-6 and IL-10 (P <0.01) cytokine ... More
The HLA-G genotype is associated with IL-10 levels in activated PBMCs.
AuthorsRizzo R, Hviid TV, Stignani M, Balboni A, Grappa MT, Melchiorri L, Baricordi OR,
JournalImmunogenetics
PubMed ID15900488
Human leukocyte antigen (HLA)-G is an MHC class Ib molecule that is expressed at the feto-maternal interface during pregnancy. However, recent results have also shown that it may have important functions as an immuno-modulatory factor in adult life. Differences in the pattern of alternative splicing and in the stability of ... More
High levels of circulating interleukin-10 in diabetic nephropathy patients.
AuthorsMysliwska J, Zorena K, Semetkowska-Jurkiewicz E, Rachon D, Suchanek H, Mysliwski A,
JournalEur Cytokine Netw
PubMed ID15941682
The aim of our study was to analyse the level of circulating interleukin-10 (IL-10) and relate it to the grade of albuminuria in patients with diabetic nephropathy (DN) due to type 1 diabetes mellitus (DM). Since IL-10 has met the criteria for an anti-inflammatory and an immunosuppressive cytokine, its activity ... More
Minocycline attenuates T cell and microglia activity to impair cytokine production in T cell-microglia interaction.
AuthorsGiuliani F, Hader W, Yong VW,
JournalJ Leukoc Biol
PubMed ID15817702
Minocycline, a tetracycline with anti-inflammatory properties, has been reported to down-regulate the activity of microglia, whose activation occurs in inflammatory and degenerative diseases of the central nervous system, such as multiple sclerosis and Alzheimer's disease. In these disorders, a T cell component is also evident, and we have demonstrated previously ... More
Maternal Trypanosoma cruzi infection upregulates capacity of uninfected neonate cells To produce pro- and anti-inflammatory cytokines.
AuthorsVekemans J, Truyens C, Torrico F, Solano M, Torrico MC, Rodriguez P, Alonso-Vega C, Carlier Y,
JournalInfect Immun
PubMed ID10948177
The possibility of maternal in utero modulation of the innate and/or adaptive immune responses of uninfected newborns from Trypanosoma cruzi-infected mothers was investigated by studying the capacity of their whole blood cells to produce cytokines in response to T. cruzi lysate or lipopolysaccharide-plus-phytohemagglutinin (LPS-PHA) stimulation. Cells of such newborns occasionally ... More