Selective inhibition of interleukin-4 gene expression in human T cells by aspirin.
AuthorsCianferoni A, Schroeder JT, Kim J, Schmidt JW, Lichtenstein LM, Georas SN, Casolaro V,
JournalBlood
PubMed ID11238116
'Previous studies indicated that aspirin (acetylsalicylic acid [ASA]) can have profound immunomodulatory effects by regulating cytokine gene expression in several types of cells. This study is the first in which concentrations of ASA in the therapeutic range were found to significantly reduce interleukin (IL)-4 secretion and RNA expression in freshly ... More
Induction of phagocyte-stimulating and Th1-promoting cytokines by in vitro stimulation of human peripheral blood mononuclear cells with Streptococcus pneumoniae.
AuthorsArvå E, Andersson B,
JournalScand J Immunol
PubMed ID10219769
'Polymorphonuclear granulocytes, which provide a major defence against Streptococcus pneumoniae infections, are attracted to and activated by various cytokines. The aim of this study was to analyse the cytokine response of human peripheral blood mononuclear cells to stimulation with S. pneumoniae. Strains belonging to serogroups 4, 6, 14, 19 or ... More
IL-13 and IFN-gamma secretion by activated T cells in HIV-1 infection associated with viral suppression and a lack of disease progression.
AuthorsBailer RT, Holloway A, Sun J, Margolick JB, Martin M, Kostman J, Montaner LJ,
JournalJ Immunol
PubMed ID10358209
'The immunopathology of HIV-1 infection includes immune defects in T cell cytokine secretion, resulting in decreased Ag-specific responses. In this report, IL-13 and IFN-gamma were analyzed in progressive HIV-1 disease. Both cytokines exert positive effects on Ag presentation and inhibit HIV-1 infection of macrophages. Anti-CD3/anti-CD28-activated PBMC from HIV-1-infected individuals (n ... More
Relationship between group-specific component protein and the development of asthma.
AuthorsLee SH, Kim KH, Kim JM, Yoon SH, Kim TH, Park SW, Park JS, Uh ST, Lee HS, Kim YH
JournalAm J Respir Crit Care Med
PubMed ID21169467
Airway inflammation and remodeling during asthma are attributed to the altered expression of biologically relevant proteins.
Modulation of T-cell function by (R)- and (S)-isomers of albuterol: anti-inflammatory influences of (R)-isomers are negated in the presence of the (S)-isomer.
AuthorsBaramki D, Koester J, Anderson AJ, Borish L,
JournalJ Allergy Clin Immunol
PubMed ID11897990
beta(2)-Adrenergic agonists interact with specific receptors on T lymphocytes to mediate anti-inflammatory activities. However, anti-inflammatory effects are not observed when beta(2)-adrenergic agonists are administered in vivo as racemates. We hypothesized that anti-inflammatory influences are mediated by the (R)-isomer and are masked in the additional presence of the (S)-isomer. Antigen-specific T-cell ... More