Serum IL-8 and MCP-1 concentration do not identify patients with enlarging contusions after traumatic brain injury.
AuthorsRhodes J, Sharkey J, Andrews P,
JournalJ Trauma
PubMed ID19509619
'Cerebral contusions contain numerous leukocytes, and a temporal relationship exists among cerebral chemokine expression, leukocyte recruitment, and contusion enlargement. This would suggest a role for chemokines in contusion development. However, it has not been established if serum concentrations of chemokines such as interleukin-8 (IL-8) or monocyte chemoattractant protein-1 (MCP-1) change ... More
Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada disease.
AuthorsMiyazawa I, Abe T, Narikawa K, Feng J, Misu T, Nakashima I, Fujimori J, Tamai M, Fujihara K, Itoyama Y,
JournalJ Neuroimmunol
PubMed ID15589059
'We analyzed the concentrations of four chemokines in the cerebrospinal fluid (CSF) and sera in Vogt-Koyanagi-Harada disease (VKH), an autoimmune uveomeningitis syndrome against melanocyte-associated proteins, with ELISA. CSF-CXCL10/IP-10 and CSF-CCL17/TARC were significantly elevated in VKH than in controls. In the majority of VKH cases and controls, CSF-CXCL10 was higher than ... More
Vascular endothelial growth factor and monocyte chemoattractant protein-1 in Behçet's patients with venous thrombosis.
AuthorsBozoglu E, Dinc A, Erdem H, Pay S, Simsek I, Kocar IH,
JournalClin Exp Rheumatol
PubMed ID16273763
'Vascular lesions can involve both arterial and venous systems which are often the major causes complicating the disease course of Behçet''s disease (BD). Vascular endothelial growth factor (VEGF) is a stimulant of angiogenesis secondary to ischemia while monocyte chemoattractant protein 1 (MCP-1) is induced by shear stresses leading to vascular ... More
Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells.
AuthorsAgaugué S, Marcenaro E, Ferranti B, Moretta L, Moretta A,
JournalBlood
PubMed ID18579793
'Dendritic cells (DCs) play a crucial role in naive T-cell priming. Recent data suggested that natural killer (NK) cells can influence the capability of DCs to promote Th1 polarization. This regulatory function is primarily mediated by cytokines released in the microenvironment during inflammatory responses involving NK cells. In this study, ... More
CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis.
AuthorsNarikawa K, Misu T, Fujihara K, Nakashima I, Sato S, Itoyama Y,
JournalJ Neuroimmunol
PubMed ID15020078
The pathogenesis of relapsing neuromyelitis optica (RNMO) remains unknown. We, for the first time, studied the levels of four chemokines in the cerebrospinal fluid in RNMO with ELISA and compared the data with those in multiple sclerosis (MS) and control. CXCL10/IP-10 and CCL17/TARC were significantly elevated in both RNMO and ... More
Long-term high intake of whole proteins results in renal damage in pigs.
AuthorsJia Y, Hwang SY, House JD, Ogborn MR, Weiler HA, O K, Aukema HM,
JournalJ Nutr
PubMed ID20668252
Despite evidence of potential antiobesity effects of high-protein (HP) diets, the impact of consuming diets with protein levels at the upper limit of the acceptable macronutrient distribution range (AMDR) on kidney health is unknown. To test whether HP diets affect renal health, whole plant and animal proteins in proportions that ... More
Effect of hyaluronan-supplemented dialysate on in vitro function of human peritoneal mesothelial cells.
AuthorsBreborowicz A, Pyda M, Moberly J, Martis L, Oreopoulos D,
JournalAm J Nephrol
PubMed ID15148458
Addition of hyaluronan (HA) to the dialysis solution has been suggested as a means to protect the peritoneum from injury during peritoneal dialysis (PD). Concentrations of inflammatory mediators were determined in dialysate samples obtained from PD patients after 6-hour dwells with glucose-based (13.6 g/l) solution containing 0.1 and 0.5 g/l ... More
Essential role of monocyte chemoattractant protein-1 in development of restenotic changes (neointimal hyperplasia and constrictive remodeling) after balloon angioplasty in hypercholesterolemic rabbits.
AuthorsMori E, Komori K, Yamaoka T, Tanii M, Kataoka C, Takeshita A, Usui M, Egashira K, Sugimachi K,
JournalCirculation
PubMed ID12070121
Renarrowing of dilated arterial sites (restenosis) hampers the clinical benefits of coronary angioplasty. Infiltration and activation of monocytes in the arterial wall mediated by monocyte chemoattractant protein-1 (MCP-1) might be a major cause of restenosis after angioplasty. However, there is no direct evidence to support a definite role of MCP-1 ... More