Rosuvastatin therapy does not affect serum MMP-13 or TIMP-1 levels in hypercholesterolemic patients.
AuthorsCevik C, Nugent K, Meyerrose G, Otahbachi M, Izgi C, Lyte M, Fish RD,
JournalTex Heart Inst J
PubMed ID21720458
Matrix metalloproteinases degrade the collagen content of atherosclerotic plaque and reduce plaque stability. In tissue sections of atherosclerotic plaque, the expression of matrix metalloproteinases is increased. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) decrease the tissue expression of matrix metalloproteinases-1, -2, -3, and -9 in atheromatous plaque by attenuating the inflammatory ... More
Biomarkers for abdominal aortic aneurysms from a sex perspective.
'Abdominal aortic aneurysms (AAAs) differ in men and women. Women are older at diagnosis, have a higher risk of rupture, and worse outcome after surgery compared with men. The higher occurrence of AAAs in men accounts for the dominance of men in biomarker analyses. The primary aim of this study ... More
Runx3 suppresses gastric cancer metastasis through inactivation of MMP9 by upregulation of TIMP-1.
AuthorsChen Y, Wei X, Guo C, Jin H, Han Z, Han Y, Qiao T, Wu K, Fan D,
JournalInt J Cancer
PubMed ID21128246
Recent studies have suggested that loss of RUNX3 expression is involved with gastric tumor metastasis. However, the precise mechanism of RUNX3-mediated suppression of tumor metastasis remains elusive. We aimed to clarify the effect of RUNX3 on tumor metastasis in gastric cancer cell lines and tumors. Immunohistochemistry revealed that RUNX3 was ... More