Matrix metalloproteinase-9 genotype as a potential genetic marker for abdominal aortic aneurysm.
AuthorsDuellman T, Warren CL, Peissig P, Wynn M, Yang J,
JournalCirc Cardiovasc Genet
PubMed ID22942228
Degradation of extracellular matrix support in the large abdominal arteries contribute to abnormal dilation of aorta, leading to abdominal aortic aneurysms, and matrix metalloproteinase-9 (MMP-9) is the predominant enzyme targeting elastin and collagen present in the walls of the abdominal aorta. Previous studies have suggested a potential association between MMP-9 ... More
Biomarkers for abdominal aortic aneurysms from a sex perspective.
'Abdominal aortic aneurysms (AAAs) differ in men and women. Women are older at diagnosis, have a higher risk of rupture, and worse outcome after surgery compared with men. The higher occurrence of AAAs in men accounts for the dominance of men in biomarker analyses. The primary aim of this study ... More
Preservation of tear film integrity and inhibition of corneal injury by dexamethasone in a rabbit model of lacrimal gland inflammation-induced dry eye.
AuthorsNagelhout TJ, Gamache DA, Roberts L, Brady MT, Yanni JM,
JournalJ Ocul Pharmacol Ther
PubMed ID15857280
'The aim of this study was to establish a clinically relevant short-term animal model of dry eye with utility in identifying compounds with potential therapeutic efficacy. Rabbit lacrimal glands were injected with the T-cell mitogen Concanavalin A (Con A) and inflammation, tear function, and corneal epithelial cell integrity were subsequently ... More
Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation.
AuthorsCioce M, Canino C, Goparaju C, Yang H, Carbone M, Pass HI,
Journal
PubMed ID24722292
Clinical management of malignant pleural mesothelioma (MPM) is very challenging because of the uncommon resistance of this tumor to chemotherapy. We report here increased expression of macrophage colony-stimulating-factor-1-receptor (M-CSF/CSF-1R) mRNA in mesothelioma versus normal tissue specimens and demonstrate that CSF-1R expression identifies chemoresistant cells of mesothelial nature in both primary ... More
Effects of benzalkonium chloride- or polyquad-preserved fixed combination glaucoma medications on human trabecular meshwork cells.
AuthorsAmmar DA, Kahook MY,
JournalMol Vis
PubMed ID21750606
We investigated the potential short and long-term effects in cultured human trabecular meshwork (TM) cells of various topical glaucoma formulations containing different preservatives. We tested the fixed combination medications 0.004% travoprost plus 0.5% timolol preserved with either 0.015% benzalkonium chloride (BAK; DuoTrav®), or with 0.001% polyquad (PQ; DuoTrav(®) BAK-free); and ... More