Systemic increase in type I interferon activity in Sjögren's syndrome: a putative role for plasmacytoid dendritic cells.
AuthorsWildenberg ME, van Helden-Meeuwsen CG, van de Merwe JP, Drexhage HA, Versnel MA,
JournalEur J Immunol
PubMed ID18581327
'In the salivary glands of primary Sjögren''s syndrome (pSjS) patients, type I IFN activity is increased, but systemic levels of type I IFN proteins are rarely detected. This study focused on the systemic activity of type I IFN in pSjS, as well as the role of peripheral plasmacytoid dendritic cells ... More
Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood.
AuthorsJing Y, Shaheen E, Drake RR, Chen N, Gravenstein S, Deng Y,
JournalHum Immunol
PubMed ID19596035
Dendritic cells (DC) are potent antigen-presenting cells that initiate and regulate T-cell responses. In this study, the numbers and functional cytokine secretions of plasmacytoid and myeloid DC (pDC and mDC, respectively) in peripheral blood from young and elderly subjects were compared. Overall, pDC numbers in peripheral blood were lower in ... More
Concentrations and significance of cytokines and other immunologic factors in semen of healthy fertile men.
AuthorsPolitch JA, Tucker L, Bowman FP, Anderson DJ,
JournalHum Reprod
PubMed ID17855405
The purpose of this study was to establish normal reference values for several immunologic factors in semen to provide a foundation for understanding their physiologic significance in health and disease. Semen from 83 healthy, fertile men was assessed by Bio-Plex or enzyme-linked immunosorbent assay to determine quantities of immunoglobulin (Ig) ... More