Drosha regulates hMSCs cell cycle progression through a miRNA independent mechanism.
AuthorsOskowitz AZ, Penfornis P, Tucker A, Prockop DJ, Pochampally R,
JournalInt J Biochem Cell Biol
PubMed ID21794839
'Recently we demonstrated that the miRNA regulate human mesenchymal stem cells (hMSCs) differentiation. To determine the role of the miRNA pathway in hMSCs proliferation, Drosha and Dicer knockdown hMSCs were generated using a lentiviral based tetracycline inducible shRNA. hMSCs with reduced Drosha expression had a significantly reduced proliferation rate, while ... More
Growth inhibitory effects of celecoxib in human umbilical vein endothelial cells are mediated through G1 arrest via multiple signaling mechanisms.
AuthorsLin HP, Kulp SK, Tseng PH, Yang YT, Yang CC, Chen CS, Chen CS,
JournalMol Cancer Ther
PubMed ID15634661
Evidence suggests that the angiogenic endothelium represents an important target through which celecoxib mediates in vivo antitumor effects. Nevertheless, the pharmacologic basis for celecoxib-caused growth inhibition in endothelial cells in vitro remains to be defined. Previously, we showed that celecoxib-induced apoptosis in PC-3 prostate cancer cells was mediated in part ... More