Corticotropin-releasing hormone induces vascular endothelial growth factor release from human mast cells via the cAMP/protein kinase A/p38 mitogen-activated protein kinase pathway.
AuthorsCao J, Cetrulo CL, Theoharides TC,
JournalMol Pharmacol
PubMed ID16332989
'Mast cells are involved in allergic reactions but also in innate immunity and inflammation. Corticotropin-releasing hormone (CRH), the key regulator of the hypothalamic-pituitary-adrenal axis, also has proinflammatory effects, apparently through mast cells. We showed recently that CRH selectively stimulates human leukemic mast cells and human umbilical cord blood-derived mast cells ... More
Basic fibroblast growth factor-induced cell death is effected through sustained activation of p38MAPK and up-regulation of the death receptor p75NTR.
AuthorsWilliamson AJ, Dibling BC, Boyne JR, Selby P, Burchill SA,
JournalJ Biol Chem
PubMed ID15310753
'Basic fibroblast growth factor (bFGF) induces cell death in cells of the Ewing''s sarcoma family of tumors in vivo and in vitro. In this study we demonstrate that this is dependent on the rapid and sustained activation of p38(MAPK), in contrast to the transient activation of p38(MAPK) associated with bFGF-induced ... More
Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid arthritis synovial fibroblasts.
AuthorsBradley K, Scatizzi JC, Fiore S, Shamiyeh E, Koch AE, Firestein GS, Gorges LL, Kuntsman K, Pope RM, Moore TL, Han J, Perlman H,
JournalArthritis Rheum
PubMed ID14730602
'Rheumatoid arthritis (RA) is characterized by increased synovial lining cellularity, inflammation, and destruction of cartilage and bone. During the pathogenesis of RA, synovial fibroblasts reenter the cell cycle and multiply in number. RA synovial fibroblasts express high levels of the MAP kinase p38, which may contribute to the production of ... More
Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection.
AuthorsGarmaroudi FS, Marchant D, Si X, Khalili A, Bashashati A, Wong BW, Tabet A, Ng RT, Murphy K, Luo H, Janes KA, McManus BM,
JournalProc Natl Acad Sci U S A
PubMed ID20833815
'Signal transduction networks can be perturbed biochemically, genetically, and pharmacologically to unravel their functions. But at the systems level, it is not clear how such perturbations are best implemented to extract molecular mechanisms that underlie network function. Here, we combined pairwise perturbations with multiparameter phosphorylation measurements to reveal causal mechanisms ... More
Actinobacillus actinomycetemcomitans induces apoptosis in human monocytic THP-1 cells.
AuthorsKato S, Sugimura N, Nakashima K, Nishihara T, Kowashi Y,
JournalJ Med Microbiol
PubMed ID15713614
'It has previously been reported that the murine macrophage cell line J774.1 and the human oral epithelial cell line KB undergo apoptosis as a result of Actinobacillus actinomycetemcomitans infection. Recent studies have demonstrated that apoptosis regulation is modulated by multiple phosphorylation of several different protein kinases, including the major subtypes ... More
Subtoxic levels hydrogen peroxide-induced production of interleukin-6 by retinal pigment epithelial cells.
AuthorsWu WC, Hu DN, Gao HX, Chen M, Wang D, Rosen R, McCormick SA
JournalMol Vis
PubMed ID21031020
To study the effect of subtoxic levels of hydrogen peroxide (H(2)O(2)) on the expression and release of interleukin-6 (IL-6) by cultured retinal pigment epithelial (RPE) cells and to explore the relevant signal pathways. ... More
Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappaB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells.
AuthorsWhiteman M, Spencer JP, Zhu YZ, Armstrong JS, Schantz JT
JournalOsteoarthritis Cartilage
PubMed ID16427328
Peroxynitrite (ONOO(-)) is formed in the inflamed and degenerating human joint. Peroxynitrite-modified collagen-II (PMC-II) was recently discovered in the serum of patients with osteoarthritis (OA) and rheumatoid arthritis (RA). Therefore we investigated the cellular effects of PMC-II on human mesenchymal progenitor cells (MPCs) as a model of cartilage and cartilage ... More
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction.
AuthorsTakuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKhann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K, Yan SS,
JournalProc Natl Acad Sci U S A
PubMed ID19901339
Intracellular amyloid-beta peptide (Abeta) has been implicated in neuronal death associated with Alzheimer's disease. Although Abeta is predominantly secreted into the extracellular space, mechanisms of Abeta transport at the level of the neuronal cell membrane remain to be fully elucidated. We demonstrate that receptor for advanced glycation end products (RAGE) ... More
Anti-inflammatory activity of sertaconazole nitrate is mediated via activation of a p38-COX-2-PGE2 pathway.
AuthorsSur R, Babad JM, Garay M, Liebel FT, Southall MD,
JournalJ Invest Dermatol
PubMed ID17637821
Sertaconazole nitrate is an antifungal agent that exhibits anti-inflammatory activity; however, the mechanism for this action was unknown. We investigated the cellular mechanisms by which sertaconazole exerts its anti-inflammatory activity in keratinocytes and human peripheral blood mononuclear cells (PBMCs). Paradoxically, sertaconazole was found to activate the proinflammatory p38 mitogen-activated protein ... More
Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells.
Autosomal dominant Parkinson disease (PD) is caused by duplication or triplication of the alpha-synuclein gene as well as by the A30P, E46K, and A53T mutations. The mechanisms are unknown. Reactive astrocytes in the substantia nigra of PD and MPTP-treated monkeys display high levels of the inflammatory mediator intercellular adhesion molecule-1 ... More