Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathway.
AuthorsHu DN, Chen M, Zhang DY, Ye F, McCormick SA, Chan CC
JournalInvest Ophthalmol Vis Sci
PubMed ID21398280
Melanocyte is the major cell component in the uvea. Interleukin (IL)-6 is a proinflammatory cytokine. The authors studied the expression of IL-6 in cultured human uveal melanocytes (UMs) and their modulation by IL-1ß and explored the relevant signal pathways. ... More
Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappaB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells.
AuthorsWhiteman M, Spencer JP, Zhu YZ, Armstrong JS, Schantz JT
JournalOsteoarthritis Cartilage
PubMed ID16427328
Peroxynitrite (ONOO(-)) is formed in the inflamed and degenerating human joint. Peroxynitrite-modified collagen-II (PMC-II) was recently discovered in the serum of patients with osteoarthritis (OA) and rheumatoid arthritis (RA). Therefore we investigated the cellular effects of PMC-II on human mesenchymal progenitor cells (MPCs) as a model of cartilage and cartilage ... More
Impairment of insulin receptor signal transduction in placentas of intra-uterine growth-restricted newborns and its relationship with fetal growth.
AuthorsStreet ME, Viani I, Ziveri MA, Volta C, Smerieri A, Bernasconi S,
JournalEur J Endocrinol
PubMed ID20930063
Intra-uterine growth restriction (IUGR) is related to a higher incidence of type 2 diabetes mellitus. We previously reported reduced adiponectin and increased interleukin 6 (IL6) concentrations in IUGR placentas, which are features of insulin resistance. We aimed to investigate placental insulin receptor (IR) function and activation in human placenta and ... More