Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor.
AuthorsTerajima M, Inoue T, Magari K, Yamazaki H, Higashi Y, Mizuhara H,
JournalEur J Pharmacol
PubMed ID23183108
'Given the key role p38 mitogen-activated protein kinase (MAPK) plays in inflammatory responses through the production of cytokines and inflammatory mediators, its inhibition is considered a promising therapeutic strategy for chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, inflammatory bowel disease, and chronic obstructive pulmonary disease. Here, we evaluated the ... More
Dexamethasone induction of a heat stress response.
AuthorsGuerrero JA, Vicente V, Corral J,
JournalMethods Enzymol
PubMed ID21266247
Dexamethasone is a potent, synthetic member of the glucocorticoid class of steroid drugs with pleiotropic effects on multiple signaling pathways, and has been widely used in many disorders during the last 50 years. Recent studies sustain a role of this drug in the heat stress response, increasing the levels of ... More
Controlled delivery of heat shock protein using an injectable microsphere/hydrogel combination system for the treatment of myocardial infarction.
AuthorsLee J, Tan CY, Lee SK, Kim YH, Lee KY,
JournalJ Control Release
PubMed ID19374930
Myocardial infarction causes a high rate of morbidity and mortality worldwide, and heat shock proteins as molecular chaperones have been attractive targets for protecting cardiomyoblasts under environmental stimuli. In this study, in order to enhance the penetration of heat shock protein 27 (HSP27) across cell membranes, we fused HSP27 with ... More