Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection.
AuthorsGarmaroudi FS, Marchant D, Si X, Khalili A, Bashashati A, Wong BW, Tabet A, Ng RT, Murphy K, Luo H, Janes KA, McManus BM,
JournalProc Natl Acad Sci U S A
PubMed ID20833815
'Signal transduction networks can be perturbed biochemically, genetically, and pharmacologically to unravel their functions. But at the systems level, it is not clear how such perturbations are best implemented to extract molecular mechanisms that underlie network function. Here, we combined pairwise perturbations with multiparameter phosphorylation measurements to reveal causal mechanisms ... More
Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer.
AuthorsStraume O, Shimamura T, Lampa MJ, Carretero J, Oyan AM, Jia D, Borgman CL, Soucheray M, Downing SR, Short SM, Kang SY, Wang S, Chen L, Collett K, Bachmann I, Wong KK, Shapiro GI, Kalland KH, Folkman J, Watnick RS, Akslen LA, Naumov GN
JournalProc Natl Acad Sci U S A
PubMed ID22589302
'The mechanisms underlying tumor dormancy have been elusive and not well characterized. We recently published an experimental model for the study of human tumor dormancy and the role of angiogenesis, and reported that the angiogenic switch was preceded by a local increase in VEGF-A and basic fibroblast growth factor. In ... More
Galvanic zinc-copper microparticles produce electrical stimulation that reduces the inflammatory and immune responses in skin.
AuthorsKaur S, Lyte P, Garay M, Liebel F, Sun Y, Liu JC, Southall MD,
JournalArch Dermatol Res
PubMed ID21465312
'The human body has its own innate electrical system that regulates the body''s functions via communications among organs through the well-known neural system. While the effect of low-level electrical stimulation on wound repair has been reported, few studies have examined the effect of electric potential on non-wounded, intact skin. A ... More
Anti-inflammatory activity of sertaconazole nitrate is mediated via activation of a p38-COX-2-PGE2 pathway.
AuthorsSur R, Babad JM, Garay M, Liebel FT, Southall MD,
JournalJ Invest Dermatol
PubMed ID17637821
Sertaconazole nitrate is an antifungal agent that exhibits anti-inflammatory activity; however, the mechanism for this action was unknown. We investigated the cellular mechanisms by which sertaconazole exerts its anti-inflammatory activity in keratinocytes and human peripheral blood mononuclear cells (PBMCs). Paradoxically, sertaconazole was found to activate the proinflammatory p38 mitogen-activated protein ... More