Subtoxic levels hydrogen peroxide-induced production of interleukin-6 by retinal pigment epithelial cells.
AuthorsWu WC, Hu DN, Gao HX, Chen M, Wang D, Rosen R, McCormick SA
JournalMol Vis
PubMed ID21031020
To study the effect of subtoxic levels of hydrogen peroxide (H(2)O(2)) on the expression and release of interleukin-6 (IL-6) by cultured retinal pigment epithelial (RPE) cells and to explore the relevant signal pathways. ... More
Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathway.
AuthorsHu DN, Chen M, Zhang DY, Ye F, McCormick SA, Chan CC
JournalInvest Ophthalmol Vis Sci
PubMed ID21398280
Melanocyte is the major cell component in the uvea. Interleukin (IL)-6 is a proinflammatory cytokine. The authors studied the expression of IL-6 in cultured human uveal melanocytes (UMs) and their modulation by IL-1ß and explored the relevant signal pathways. ... More
All-trans-retinoic acid prevents radiation- or bleomycin-induced pulmonary fibrosis.
AuthorsTabata C, Kadokawa Y, Tabata R, Takahashi M, Okoshi K, Sakai Y, Mishima M, Kubo H
JournalAm J Respir Crit Care Med
PubMed ID17023731
Although radiotherapy is effective in treating lung cancers, resultant pulmonary injury is the main obstacle. Pulmonary fibrosis is characterized by progressive worsening in pulmonary function leading to high incidence of death. Currently, however, there has been little progress in effective preventive and therapeutic strategies. ... More
Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NF?-B activation and proinflammatory cytokine production.
AuthorsKhan AQ, Nafees S, Sultana S
JournalToxicology
PubMed ID20923693
Oxidative stress and inflammation are two major etiological factors that are suggested to play key roles in the development of ethanol induced liver injury. Release of proinflammatory cytokine like tumor necrosis factor alpha (TNF-a) and activation of nuclear factor kappa-B (NF?-B) may strongly intensify inflammation and cell damage. Additionally, reactive ... More
Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase.
AuthorsQamar W, Khan R, Khan AQ, Rehman MU, Lateef A, Tahir M, Ali F, Sultana S
JournalToxicology
PubMed ID22051199
Benzo(a)pyrene [B(a)P] is known to alter lung physiology by interfering in various intracellular pathways including alterations in NF-?B activities, cytokine release and cell survival. NF-?B suppression/activation plays a major role in cell survival status. Present investigation deals with such kind of effects of B(a)P on lungs in relation with soluble ... More