The cytotoxic and anti-proliferative effects of 3-hydrogenkwadaphnin in K562 and jurkat cells is reduced by guanosine.
AuthorsMoosavi MA, Yazdanparast R, Sanati MH,
JournalJ Biochem Mol Biol
PubMed ID16053705
'3-hydrogenwadaphnin (3-HK) is a new daphnane-type diterpene ester isolated from Dendrostellera lessertii with strong anti-tumoral activity in animal models and in cultures. Here, prolonged effects of this new agent on proliferation and viability of several different cancerous cell lines were evaluated. Using [(3)H]thymidine incorporation, it was found that the drug ... More
Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells.
AuthorsHennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN,
JournalAm J Physiol Endocrinol Metab
PubMed ID15827066
Insulin and IGF-I activate antiapoptotic pathways via insulin receptor substrate (IRS) proteins in most mammalian cells, including beta-cells. IRS-1 knockout (IRS-1KO) mice show growth retardation, hyperinsulinemia, and hyperplastic but dysfunctional islets without developing overt diabetes, whereas IRS-2KOs develop insulin resistance and islet hypoplasia leading to diabetes. Because both models display ... More
CD95-mediated apoptosis in Burkitt's lymphoma B-cells is associated with Pim-1 down-regulation.
AuthorsMatou-Nasri S, Rabhan Z, Al-Baijan H, Al-Eidi H, Yahya WB, Al Abdulrahman A, Almobadel N, Alsubeai M, Al Ghamdi S, Alaskar A, AlBalwi M, Alzahrani M, Alabdulkareem I
JournalBiochim Biophys Acta Mol Basis Dis
PubMed ID27641442
'B-cells of the high-grade non-Hodgkin lymphoma Burkitt''s lymphoma (BL) overexpress survival oncoproteins, including the proviral integration site for Moloney murine leukaemia virus kinase (Pim)-1, and become apoptosis resistant. Activated death receptor CD95 after ligation with anti-CD95 monoclonal antibody (mAb) resulted in the regression of BL via induction of apoptosis, suggesting ... More
Modelling of a hydroacoustic projector to produce low frequency sound.
AuthorsV S S, Tiwari N
JournalJ Acoust Soc Am
PubMed ID32359252
'Low frequency sound is useful in several underwater applications, including sonar, underwater communication, detection of mines, sonobuoys, detection of oil or gas deposits, etc. Hydroacoustic projectors help in generating such low frequency acoustic waves far more effectively than other devices. Even though there is sufficient information available on modelling of ... More
Evaluation of Apoptosis and Autophagy Inducing Potential of
AuthorsSengupta P, Raman S, Chowdhury R, Lohitesh K, Saini H, Mukherjee S, Paul A
JournalFront Oncol
PubMed ID29312880
'Cancer is a multifactorial disease and hence can be effectively overcome by a multi-constituently therapeutic strategy. Medicinal plant extracts represent a perfect example of such stratagem. However, minimal studies have been done till date that portray the effect of extraction techniques on the phyto-constituent profile of plant extracts and its ... More
Viola plant cyclotide vigno 5 induces mitochondria-mediated apoptosis via cytochrome C release and caspases activation in cervical cancer cells.
AuthorsEsmaeili MA, Abagheri-Mahabadi N, Hashempour H, Farhadpour M, Gruber CW, Ghassempour A
JournalFitoterapia
PubMed ID26751970
Cyclotides describe a unique cyclic peptide family that displays a broad range of biological activities including uterotonic, anti-bacteria, anti-cancer and anti-HIV. The vigno cyclotides consist of vigno 1-10 were reported recently from Viola ignobilis. In the present study, we examined the effects of vigno 5, a natural cyclopeptide from V. ... More
PEP-1-paraoxonase 1 fusion protein prevents cytokine-induced cell destruction and impaired insulin secretion in rat insulinoma cells.
AuthorsLee SJ, Kang HK, Choi YJ, Eum WS, Park J, Choi SY, Kwon HY
JournalBMB Rep
PubMed ID30269741
Pancreatic beta cell destruction and dysfunction induced by cytokines is a major cause of type 1 diabetes. Paraoxonase 1 (PON1), an arylesterase with antioxidant activity, has been shown to play an important role in preventing the development of diabetes in transgenic mice. However, no studies have examined the anti-diabetic effect ... More
Simvastatin Sensitizes Radioresistant Prostate Cancer Cells by Compromising DNA Double-Strand Break Repair.
AuthorsChen YA, Shih HW, Lin YC, Hsu HY, Wu TF, Tsai CH, Wu CL, Wu HY, Hsieh JT, Tang CH, Lai CH
JournalFront Pharmacol
PubMed ID29950990
Prostate cancer (PCa) is one of the most prevalent male cancers in western world. Radiation therapy (RT) is commonly used to treat PCa patients. However, a certain proportion of patients develop radioresistant PCa cells, which results in metastatic disease. Statins, which inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, are commonly ... More
(+)-Spectaline and Iso-6-Spectaline Induce a Possible Cross-Talk between Autophagy and Apoptosis in
AuthorsLim KT, Yeoh CY, Zainuddin Z, Ilham Adenan M
JournalTrop Med Infect Dis
PubMed ID31266222
In our previous study, two known piperidine alkaloids (+)-spectaline (