CD25 shedding by human natural occurring CD4+CD25+ regulatory T cells does not inhibit the action of IL-2.
AuthorsPedersen AE, Lauritsen JP,
JournalScand J Immunol
PubMed ID19522766
Regulatory T (Treg) cells are important for the maintenance of peripheral tolerance and inhibition of pathogenic T-cell responses. Therefore, they are important for the limitation of chronic inflammation but can also be deleterious by e.g. limiting antitumour immune responses. Natural occurring Tregs are known to inhibit CD4+ T cell in ... More
Lymphocyte modulation in a baboon model of immunosenescence.
AuthorsJayashankar L, Brasky KM, Ward JA, Attanasio R,
JournalClin Diagn Lab Immunol
PubMed ID12965919
The age-related modulation of lymphocyte number and function was assessed in a nonhuman primate model consisting of healthy olive baboons (Papio cynocephalus anubis) of ages encompassing the entire life span of this species. The objectives of this study were to characterize an animal model of immunosenescence and to assess whether ... More
Investigating the role of immunomodulation for colon cancer prevention: results of an in vivo dose escalation trial of levamisole with immunologic endpoints.
AuthorsHolcombe RF, Milovanovic T, Stewart RM, Brodhag TM,
JournalCancer Detect Prev
PubMed ID11341354
The potential role of immunomodulatory agents for colon cancer prevention has not been studied systematically. Levamisole (LMS), which is immunostimulatory, is synergistic with 5-fluorouracil in the adjuvant therapy of patients with stage III colon cancer. This pilot study was initiated to explore the potential utility of LMS as a colon ... More