Neutrophils are essential for rapid clearance of Enterococcus faecium in mice.
AuthorsLeendertse M, Willems RJ, Giebelen IA, Roelofs JJ, Bonten MJ, van der Poll T,
JournalInfect Immun
PubMed ID19001080
'A progressive increase in infections with multiresistant Enterococcus faecium has been reported, especially in cancer patients and neutropenic patients. Despite its increasing importance as a nosocomial pathogen, knowledge of the pathogenesis of E. faecium infections is highly limited. In this study, we investigated the role of neutrophils during peritonitis with ... More
Hyperosmotic stress contributes to mouse colonic inflammation through the methylation of protein phosphatase 2A.
AuthorsSchwartz L, Abolhassani M, Pooya M, Steyaert JM, Wertz X, Israël M, Guais A, Chaumet-Riffaud P,
JournalAm J Physiol Gastrointest Liver Physiol
PubMed ID18755808
'There are several reports suggesting hyperosmotic contents in the feces of patients suffering from inflammatory bowel disease (IBD). Previous works have documented that hyperosmolarity can cause inflammation attributable to methylation of the catalytic subunit of protein phosphatase 2A (PP2A) and subsequent NF-kappaB activation resulting in cytokine secretion. In this study, ... More
Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice.
AuthorsPini M, Gove ME, Fayad R, Cabay RJ, Fantuzzi G,
JournalAm J Physiol Gastrointest Liver Physiol
PubMed ID19074637
The goal of this study was to investigate the role of the adipokine adiponectin (APN) in development of spontaneous colitis in IL-10 knockout (KO) mice. To this aim, we generated double IL-10 APN KO mice and compared their disease development to that of single IL-10 KO mice. Both IL-10 KO ... More
Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice.
AuthorsMoukdar F, Robidoux J, Lyght O, Pi J, Daniel KW, Collins S,
JournalJ Lipid Res
PubMed ID18698091
Vascular dysfunction in response to reactive oxygen species (ROS) plays an important role in the development and progression of atherosclerotic lesions. In most cells, mitochondria are the major source of cellular ROS during aerobic respiration. Under most conditions the rates of ROS formation and elimination are balanced through mechanisms that ... More