p53 is an important regulator of CCL2 gene expression.
AuthorsTang X, Asano M, O'Reilly A, Farquhar A, Yang Y, Amar S,
JournalCurr Mol Med
PubMed ID22804246
The p53 protein is a sequence-specific DNA-binding factor that regulates inflammatory genes such as CCL2/MCP-1 that may play a role in various diseases. A recent study has indicated that the knockdown of human p53 leads to a strong negative regulation of CCL2 induction. We are therefore interested in how p53 ... More
Effect of flunixin meglumine on cytokine levels in experimental endotoxemia in mice.
AuthorsYazar E, Er A, Uney K, Altunok V, Elmas M,
JournalJ Vet Med A Physiol Pathol Clin Med
PubMed ID17718807
In this study, effect of flunixin meglumine on serum tumour necrosis factor alpha, (TNFalpha) interleukin-1 beta and interleukin-10 levels was investigated in lipopolysaccharide-induced endotoxic mice. Healthy 273 Balb/C mice were used and divided into three equal groups. Group 1 was injected lipopolysaccharide (Escherichia coli 0111:B4, 250 microg/mouse, intraperitoneally), Group 2 ... More