Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-? activity in dendritic cells.
AuthorsLegutko A, Marichal T, Fiévez L, Bedoret D, Mayer A, de Vries H, Klotz L, Drion PV, Heirman C, Cataldo D, Louis R, Thielemans K, Andris F, Leo O, Lekeux P, Desmet CJ, Bureau F
JournalJ Immunol
PubMed ID21948987
'Sirtuins are a unique class of NAD(+)-dependent deacetylases that regulate diverse biological functions such as aging, metabolism, and stress resistance. Recently, it has been shown that sirtuins may have anti-inflammatory activities by inhibiting proinflammatory transcription factors such as NF-?B. In contrast, we report in this study that pharmacological inhibition of ... More
Immunosuppression after endotoxin shock: the result of multiple anti-inflammatory factors.
AuthorsJunger WG, Hoyt DB, Liu FC, Loomis WH, Coimbra R,
JournalJ Trauma
PubMed ID8614067
'Endotoxin induced suppression of cellular immune function is thought to contribute to septic complications in trauma patients. A rabbit model of endotoxemia was used to determine the relative roles of the anti-inflammatory factors interleukin-4 (IL-4), interleukin-10 (IL-10), transforming growth factor beta1 (TGFbeta1), and prostaglandin E2 (PGE2) in addition to other ... More