In vivo screening for secreted proteins that modulate glucose handling identifies interleukin-6 family members as potent hypoglycemic agents.
AuthorsChen CA, Carolan PC, Annes JP,
JournalPLoS One
PubMed ID22962620
Diabetes is a disease of abnormal glucose homeostasis characterized by chronic hyperglycemia and a broad array of consequent organ damage. Because normal glucose homeostasis is maintained by a complex interaction between behavior (feeding and physical activity) and metabolic activity that is modulated by inter-organ signaling through secreted factors, disease modeling ... More
MCP-1 expression in endotoxin-induced uveitis.
AuthorsTuaillon N, Shen DF, Berger RB, Lu B, Rollins BJ, Chan CC,
JournalInvest Ophthalmol Vis Sci
PubMed ID11980865
Monocyte chemoattractant protein (MCP)-1 (CCL-2) is a chemokine with chemoattractant properties for monocytes, memory T cells, natural killer cells, mast cells, and basophils. To delineate the role played by MCP-1 in acute anterior uveitis, a common ocular inflammation, MCP-1(-/-) mice and wild-type matched control mice were analyzed for the development ... More