Effect of flunixin meglumine on cytokine levels in experimental endotoxemia in mice.
AuthorsYazar E, Er A, Uney K, Altunok V, Elmas M,
JournalJ Vet Med A Physiol Pathol Clin Med
PubMed ID17718807
In this study, effect of flunixin meglumine on serum tumour necrosis factor alpha, (TNFalpha) interleukin-1 beta and interleukin-10 levels was investigated in lipopolysaccharide-induced endotoxic mice. Healthy 273 Balb/C mice were used and divided into three equal groups. Group 1 was injected lipopolysaccharide (Escherichia coli 0111:B4, 250 microg/mouse, intraperitoneally), Group 2 ... More
Methyl palmitate inhibits lipopolysaccharide-stimulated phagocytic activity of rat peritoneal macrophages.
AuthorsSarkar S, Khan MF, Kaphalia BS, Ansari GA,
JournalJ Biochem Mol Toxicol
PubMed ID17163484
Macrophages, in general, are critical effectors of body's immune system. Chemical inhibition of phagocytic activity of such macrophages as Kupffer cells has been extensively studied. We have earlier shown that methyl palmitate (MP) inhibits the activation of Kupffer cells. To evaluate the potential of MP to inhibit the activation of ... More
Anti-inflammatory and antifibrotic effects of methyl palmitate.
AuthorsEl-Demerdash E,
JournalToxicol Appl Pharmacol
PubMed ID21575650
Methyl palmitate (MP) has been shown earlier to inhibit Kupffer cells and rat peritoneal macrophages. To evaluate the potential of MP to inhibit the activation of other macrophages, RAW cells (macrophages of alveolar origin) were treated with varying concentrations of MP (0.25, 0.5, 1mM). Assessment of cytotoxicity using MTT assay ... More