AuthorsTuaillon N, Shen DF, Berger RB, Lu B, Rollins BJ, Chan CC,
JournalInvest Ophthalmol Vis Sci
PubMed ID11980865
Monocyte chemoattractant protein (MCP)-1 (CCL-2) is a chemokine with chemoattractant properties for monocytes, memory T cells, natural killer cells, mast cells, and basophils. To delineate the role played by MCP-1 in acute anterior uveitis, a common ocular inflammation, MCP-1(-/-) mice and wild-type matched control mice were analyzed for the development ... More
p53 is an important regulator of CCL2 gene expression.
AuthorsTang X, Asano M, O'Reilly A, Farquhar A, Yang Y, Amar S,
JournalCurr Mol Med
PubMed ID22804246
The p53 protein is a sequence-specific DNA-binding factor that regulates inflammatory genes such as CCL2/MCP-1 that may play a role in various diseases. A recent study has indicated that the knockdown of human p53 leads to a strong negative regulation of CCL2 induction. We are therefore interested in how p53 ... More
AuthorsTang X, O'Reilly A, Asano M, Merrill JC, Yokoyama KK, Amar S,
JournalCurr Mol Med
PubMed ID21663590
'Abnormal and prolonged inflammatory reaction is seen in a wide variety of disorders, and high level of Tumor Necrosis Factor alpha (TNF-a) has been linked to these disorders. Therefore, modulation of TNF-a expression is important in the regulation of inflammatory disorders. In our previous study, we have shown that a ... More
The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice.
AuthorsAgah A, Kyriakides TR, Lawler J, Bornstein P,
JournalAm J Pathol
PubMed ID12213711
'Thrombospondin (TSP) 1 and 2, share the same overall structure and interact with a number of the same cell-surface receptors. In an attempt to elucidate their biological roles more clearly, we generated double-TSP1/TSP2-null animals and compared their phenotype to those of TSP1- and TSP2-null mice. Double-null mice exhibited an apparent ... More
ER stress triggers MCP-1 expression through SET7/9-induced histone methylation in the kidneys of db/db mice.
AuthorsChen J, Guo Y, Zeng W, Huang L, Pang Q, Nie L, Mu J, Yuan F, Feng B,
Journal
PubMed ID24452638
Epigenetics plays a key role in the pathogenesis of diabetic nephropathy (DN), although the precise regulatory mechanism is still unclear. Here, we examined the role of endoplasmic reticulum (ER) stress in histone H3 lysine 4 (H3K4) methyltransferase SET7/9-induced monocyte chemoattractant protein-1 (MCP-1) expression in the kidneys of db/db mice. Our ... More
Anthocyanins from fermented berry beverages inhibit inflammation-related adiposity response in vitro.
AuthorsGarcia-Diaz DF, Johnson MH, de Mejia EG,
Journal
PubMed ID25079118
Increased adiposity has been associated with macrophage infiltration into the adipose tissue which, in turn, leads to obesity comorbidities, including type 2 diabetes. The objective of this study was to evaluate the effect of anthocyanin (ANC)-enriched fractions from blackberry-blueberry beverages on inflammation and adipogenesis in an in vitro model of ... More
Inhibition of MCP-1 and MIP-2 chemokines in murine trichinellosis: effect of the anti-inflammatory compound L-mimosine.
AuthorsFrydas S, Papaioannou N, Papazahariadou M, Hatzistilianou M, Karagouni E, Trakatelli M, Brellou G, Petrarca C, Castellani ML, Conti P, Riccioni G, Patruno A, Grilli A,
JournalInt J Immunopathol Pharmacol
PubMed ID15698514
Mimosine is a plant amino-acid which has been reported to block DNA replication in mammalian cells and to arrest cell reversibly towards the end of the G1 phase or at the beginning of the S phase. In this study, 42 mice were infected with T. spiralis a nematode parasite, and ... More
Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism.
AuthorsNorseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB,
JournalMol Cell Biol
PubMed ID22431523
Retinol-binding protein 4 (RBP4), the sole retinol transporter in blood, is secreted from adipocytes and liver. Serum RBP4 levels correlate highly with insulin resistance, other metabolic syndrome factors, and cardiovascular disease. Elevated serum RBP4 causes insulin resistance, but the molecular mechanisms are unknown. Here we show that RBP4 induces expression ... More
Clinical course of myelin oligodendrocyte glycoprotein 35-55 induced experimental autoimmune encephalomyelitis is aggravated by glia maturation factor.
AuthorsZaheer S, Wu Y, Yang X, Ahrens M, Sahu SK, Zaheer A,
JournalNeurochem Int
PubMed ID22226840
The role of glia maturation factor (GMF) in myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide-induced experimental autoimmune encephalomyelitis (EAE) was investigated using GMF-deficient (GMF-KO) mice. We demonstrate that GMF-KO mice were resistant to the MOG 35-55 peptide-induced EAE as compared to wild type (Wt) mice (two in eight versus 10 in ... More