Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation.
AuthorsZheng D, Giljohann DA, Chen DL, Massich MD, Wang XQ, Iordanov H, Mirkin CA, Paller AS,
JournalProc Natl Acad Sci U S A
PubMed ID22773805
'Topical application of nucleic acids offers many potential therapeutic advantages for suppressing genes in the skin, and potentially for systemic gene delivery. However, the epidermal barrier typically precludes entry of gene-suppressing therapy unless the barrier is disrupted. We now show that spherical nucleic acid nanoparticle conjugates (SNA-NCs), gold cores surrounded ... More
Excess type I interferon signaling in the mouse seminiferous tubules leads to germ cell loss and sterility.
AuthorsSatie AP, Mazaud-Guittot S, Seif I, Mahé D, He Z, Jouve G, Jégou B, Dejucq-Rainsford N,
JournalJ Biol Chem
PubMed ID21515676
Type I (a and ß) interferons (IFNs) elicit antiproliferative and antiviral activities via the surface receptor IFNAR. Serendipitous observations in transgenic mice in 1988 strongly suggested that IFNa/ß overexpression in the testis disrupts spermatogenesis. Here, we compare a new mouse strain transgenic for IFNß (Tg10) and a sister strain lacking ... More