Altered immune response to CNS viral infection in mice with a conditional knock-down of macrophage-lineage cells.
AuthorsCarmen J, Gowing G, Julien JP, Kerr D,
JournalGlia
PubMed ID16691560
'Neuroadapted Sindbis Virus (NSV) is a neuronotropic virus that causes hindlimb paralysis in susceptible mice and rats. The authors and others have demonstrated that though death of infected motor neurons occurs, bystander death of uninfected neurons also occurs and both contribute to the paralysis that ensues following infection. The authors ... More