Pharmacological inhibition of N-methyl d-aspartate receptor promotes secretion of vascular endothelial growth factor in müller cells: effects of hyperglycemia and hypoxia.
AuthorsCervantes-Villagrana AR, Garcia-Román J, González-Espinosa C, Lamas M,
JournalCurr Eye Res
PubMed ID20673050
'To characterize the effect of glutamate receptor activation/inhibition on the secretion of vascular endothelial growth factor (VEGF) in retina-specific glial (Müller) cells under experimental conditions of hyperglycemia and hypoxia, two intrinsic pathologic conditions of diabetic retinopathy. Purified rat Müller cells were grown in normoglycemic or diabetic-like, hyperglycemic (5.6 or 25 ... More
Integrin ß4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF.
AuthorsFan J, Cai B, Zeng M, Hao Y, Giancotti FG, Fu BM,
JournalAnn Biomed Eng
PubMed ID21556948
Prior studies have indicated that the ß4 integrin promotes mammary tumor invasion and metastasis by combining with ErbB2 and amplifying its signaling capacity. However, the effector pathways and cellular functions by which the ß4 integrin exerts these effects are incompletely understood. To examine if ß4 signaling plays a role during ... More