Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice.
AuthorsCarrithers M, Tandon S, Canosa S, Michaud M, Graesser D, Madri JA
JournalAm J Pathol
PubMed ID15632011
Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31), an adhesion molecule expressed on hematopoietic and endothelial cells, mediates apoptosis, cell proliferation, and migration and maintains endothelial integrity in addition to its roles as a modulator of lymphocyte and platelet signaling and facilitator of neutrophil transmigration. Recent data suggest that CD31 functions ... More