Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappaB.
AuthorsKang YM, Ma Y, Elks C, Zheng JP, Yang ZM, Francis J,
JournalCardiovasc Res
PubMed ID18469338
'AIMS: Nuclear factor-kappa B (NF-kappaB) is a potent inducer of pro-inflammatory cytokines (PIC) and oxidative stress in cardiovascular disease. In this study, we determined whether upregulation of NF-kappaB in the hypothalamic paraventricular nucleus (PVN) contributed to neurohumoral excitation either directly, or via interaction with the renin-angiotensin system (RAS), in heart ... More
Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction.
AuthorsIwata T, Philipovskiy A, Fisher AJ, Presson RG, Chiyo M, Lee J, Mickler E, Smith GN, Petrache I, Brand DB, Burlingham WJ, Gopalakrishnan B, Greenspan DS, Christie JD, Wilkes DS,
JournalJ Immunol
PubMed ID18832733
'Primary graft dysfunction (PGD) is a major complication following lung transplantation. We reported that anti-type V collagen (col(V)) T cell immunity was strongly associated with PGD. However, the role of preformed anti-col(V) Abs and their potential target in PGD are unknown. Col(V) immune serum, purified IgG or B cells from ... More
Microglial activation and TNFalpha production mediate altered CNS excitability following peripheral inflammation.
AuthorsRiazi K, Galic MA, Kuzmiski JB, Ho W, Sharkey KA, Pittman QJ,
JournalProc Natl Acad Sci U S A
PubMed ID18955701
Peripheral inflammation leads to a number of centrally mediated physiological and behavioral changes. The underlying mechanisms and the signaling pathways involved in these phenomena are not yet well understood. We hypothesized that peripheral inflammation leads to increased neuronal excitability arising from a CNS immune response. We induced inflammation in the ... More