Expression of the proinflammatory cytokines in cochlear explant cultures: influence of normoxia and hypoxia.
AuthorsKhan M, Szczepek AJ, Haupt H, Olze H, Mazurek B,
JournalNeurosci Lett
PubMed ID20561939
'Hearing loss can be induced by a variety of factors including hypoxia and inflammation. Here, we investigated in vitro the effect of hypoxia on the expression of proinflammatory cytokines in the explanted cochlear tissues. Using RT-PCR, we determined the expression of genes encoding IL-1beta, IL-6 and TNF in the organ ... More