In vivo screening for secreted proteins that modulate glucose handling identifies interleukin-6 family members as potent hypoglycemic agents.
AuthorsChen CA, Carolan PC, Annes JP,
JournalPLoS One
PubMed ID22962620
Diabetes is a disease of abnormal glucose homeostasis characterized by chronic hyperglycemia and a broad array of consequent organ damage. Because normal glucose homeostasis is maintained by a complex interaction between behavior (feeding and physical activity) and metabolic activity that is modulated by inter-organ signaling through secreted factors, disease modeling ... More
Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats.
'Genistein (Gen), the primary isoflavone in soy, has been shown to adversely affect various endocrine-mediated endpoints in rodents and humans. Soy formula intake by human infants has been associated with early age at menarche and decreased female-typical behavior in girls. Adipose deposition and expansion are also hormonally regulated and Gen ... More
Relevance of a Hypersaline Sodium-Rich Naturally Sparkling Mineral Water to the Protection against Metabolic Syndrome Induction in Fructose-Fed Sprague-Dawley Rats: A Biochemical, Metabolic, and Redox Approach.
AuthorsPereira CD, Severo M, Araújo JR, Guimarães JT, Pestana D, Santos A, Ferreira R, Ascensão A, Magalhães J, Azevedo I, Monteiro R, Martins MJ,
Journal
PubMed ID24672546
'The Metabolic Syndrome increases the risk for atherosclerotic cardiovascular disease and type 2 Diabetes Mellitus. Increased fructose consumption and/or mineral deficiency have been associated with Metabolic Syndrome development. This study aimed to investigate the effects of 8 weeks consumption of a hypersaline sodium-rich naturally sparkling mineral water on 10% fructose-fed ... More
Reduction of methylglyoxal-induced glycation by pyridoxamine improves adipose tissue microvascular lesions.
AuthorsRodrigues T, Matafome P, Santos-Silva D, Sena C, Seiça R,
Journal
PubMed ID23671887
'Background and Aims. Adipose tissue dysfunction results from many factors, including glycation-induced microvascular damages. We tested the usefulness of inhibiting methylglyoxal-induced glycation to adipose tissue microvasculature in this work, using the antioxidant and dicarbonyl scavenger drug pyridoxamine. Methods. A group of Wistar rats was treated daily with methylglyoxal (MG, 75?mg/Kg/day, ... More
BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes.
Thymocytes from adult BB rats can adoptively transfer autoimmune diabetes to athymic recipients. It is also known that the development of BB rat T-cells is recapitulated in adult thymus organ cultures (ATOCs). Based on these observations, we tested the hypothesis that cells capable of the adoptive transfer of diabetes would ... More