Insect lipoprotein follows a transferrin-like recycling pathway that is mediated by the insect LDL receptor homologue.
AuthorsVan Hoof D, Rodenburg KW, Van der Horst DJ
JournalJ Cell Sci
PubMed ID12356906
'The lipoprotein of insects, high-density lipophorin (HDLp), is homologous to that of mammalian low-density lipoprotein (LDL) with respect to its apolipoprotein structure. Moreover, an endocytic receptor for HDLp has been identified (insect lipophorin receptor, iLR) that is homologus to the LDL receptor. We transfected LDL-receptor-expressing CHO cells with iLR cDNA ... More
Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation.
AuthorsBurgdorf S, Kautz A, Böhnert V, Knolle PA, Kurts C
JournalScience
PubMed ID17463291
The mechanisms that allow antigen-presenting cells (APCs) to selectively present extracellular antigen to CD8+ effector T cells (cross-presentation) or to CD4+ T helper cells are not fully resolved. We demonstrated that APCs use distinct endocytosis mechanisms to simultaneously introduce soluble antigen into separate intracellular compartments, which were dedicated to presentation ... More
Cholesterol level regulates endosome motility via Rab proteins.
AuthorsChen H, Yang J, Low PS, Cheng JX,
JournalBiophys J
PubMed ID17981910
The role of cholesterol in the regulation of endosome motility was investigated by monitoring the intracellular trafficking of endocytosed folate receptors (FRs) labeled with fluorescent folate conjugates. Real-time fluorescence imaging of HeLa cells transfected with green fluorescent protein-tubulin revealed that FR-containing endosomes migrate along microtubules. Moreover, microinjection with antibodies that ... More
Dynamics and mechanisms of quantum dot nanoparticle cellular uptake.
AuthorsXiao Y, Forry SP, Gao X, Holbrook RD, Telford WG, Tona A,
JournalJ Nanobiotechnology
PubMed ID20550705
ABSTRACT: BACKGROUND: The rapid growth of the nanotechnology industry and the wide application of various nanomaterials have raised concerns over their impact on the environment and human health. Yet little is known about the mechanism of cellular uptake and cytotoxicity of nanoparticles. An array of nanomaterials has recently been introduced ... More
Plasma membrane associated location of sulfonated meso-tetraphenylporphyrins of different hydrophilicity probed by total internal reflection fluorescence spectroscopy.
Sulfonated meso-tetraphenylporphyrins of different hydrophilicity were microspectrofluorimetrically examined in endothelial cells using total internal reflection (TIR) illumination or epi-illumination. Since the penetration depth of the evanescent field during TIR illumination is limited to a few hundred nanometers, photosensitizers were almost selectively examined in close vicinity to the plasma membrane. Pronounced ... More
St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death.
Authors
JournalPLoS One
PubMed ID25076130
Photodynamic therapy with 9-hydroxypheophorbide alpha on AMC-HN-3 human head and neck cancer cells: induction of apoptosis via photoactivation of mitochondria and endoplasmic reticulum.
Authors
JournalCancer Biol Ther
PubMed ID19421004
Folate Functionalized Boron Nitride Nanotubes and their Selective Uptake by Glioblastoma Multiforme Cells: Implications for their Use as Boron Carriers in Clinical Boron Neutron Capture Therapy.