A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia.
AuthorsDuan Z, Li FQ, Wechsler J, Meade-White K, Williams K, Benson KF, Horwitz M,
JournalMol Cell Biol
PubMed ID14673143
Mutations in ELA2, encoding the human serine protease neutrophil elastase, cause cyclic and severe congenital neutropenia, and recent evidence indicates that the mutations alter the membrane trafficking of neutrophil elastase. These disorders feature impaired bone marrow production of neutrophils along with excess monocytes-terminally differentiated lineages corresponding to the two alternative ... More
A gene encoding a protein modified by the phytohormone indoleacetic acid.
Authors Walz Alexander; Park Seijin; Slovin Janet P; Ludwig-Müller Jutta; Momonoki Yoshie S; Cohen Jerry D;
JournalProc Natl Acad Sci U S A
PubMed ID11830675
'We show that the expression of an indole-3-acetic acid (IAA)-modified protein from bean seed, IAP1, is correlated to the developmental period of rapid growth during seed development. Moreover, this protein undergoes rapid degradation during germination. The gene for IAP1, the most abundant protein covalently modified by IAA (iap1, GenBank accession ... More
Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133.
AuthorsShmelkov SV, Jun L, St Clair R, McGarrigle D, Derderian CA, Usenko JK, Costa C, Zhang F, Guo X, Rafii S,
JournalBlood
PubMed ID14630820
'AC133 is a member of a novel family of cell surface proteins with 5 transmembrane domains. The function of AC133 is unknown. Although AC133 mRNA is detected in different tissues, its expression in the hematopoietic system is restricted to CD34+ stem cells. AC133 is also expressed on stem cells of ... More
Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function.
Authors Hubert Nadia; Hentze Matthias W;
JournalProc Natl Acad Sci U S A
PubMed ID12209011
'Divalent metal transporter 1 (DMT1) mediates apical iron uptake into duodenal enterocytes and also transfers iron from the endosome into the cytosol after cellular uptake via the transferrin receptor. Hence, mutations in DMT1 cause systemic iron deficiency and anemia. DMT1 mRNA levels are increased in the duodenum of iron-deficient animals. ... More
Evolution of moth sex pheromones via ancestral genes.
Authors Roelofs Wendell L; Liu Weitian; Hao Guixia; Jiao Hongmei; Rooney Alejandro P; Linn Charles E Jr;
JournalProc Natl Acad Sci U S A
PubMed ID12374851
'Mate finding in most moth species involves long-distance signaling via female-emitted sex pheromones. There is a great diversity of pheromone structures used throughout the Lepidoptera, even among closely related species. The conundrum is how signal divergence has occurred. With strong normalizing selection pressure on blend composition and response preferences, it ... More
Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle.
AuthorsGoldammer T, Zerbe H, Molenaar A, Schuberth HJ, Brunner RM, Kata SR, Seyfert HM,
JournalClin Diagn Lab Immunol
PubMed ID14715566
Coordination of the primary defense mechanisms against pathogens relies on the appropriate expression of pathogen recognition receptors (PRRs) triggering the early release of effector molecules of the innate immune system. To analyze the impact of this system on the counteraction of infections of the mammary gland (mastitis), we characterized the ... More
Gene characterized for membrane desaturase that produces (E)-11 isomers of mono- and diunsaturated fatty acids.
Moth species have evolved integral membrane desaturases that exhibit a wide diversity in substrate specificity, as well as in regiospecificity and stereospecificity of the unsaturated products. We report here the cloning and expression of a single desaturase from the sex pheromone gland of the light brown apple moth, Epiphyas postvittana, ... More
The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha.
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) is a tissue-specific coactivator that enhances the activity of many nuclear receptors and coordinates transcriptional programs important for energy metabolism. We describe here a novel PGC-1-related coactivator that is expressed in a similar tissue-specific manner as PGC-1, with the highest levels in heart and ... More