A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia.
AuthorsDuan Z, Li FQ, Wechsler J, Meade-White K, Williams K, Benson KF, Horwitz M,
JournalMol Cell Biol
PubMed ID14673143
Mutations in ELA2, encoding the human serine protease neutrophil elastase, cause cyclic and severe congenital neutropenia, and recent evidence indicates that the mutations alter the membrane trafficking of neutrophil elastase. These disorders feature impaired bone marrow production of neutrophils along with excess monocytes-terminally differentiated lineages corresponding to the two alternative ... More
A gene encoding a protein modified by the phytohormone indoleacetic acid.
Authors Walz Alexander; Park Seijin; Slovin Janet P; Ludwig-Müller Jutta; Momonoki Yoshie S; Cohen Jerry D;
JournalProc Natl Acad Sci U S A
PubMed ID11830675
'We show that the expression of an indole-3-acetic acid (IAA)-modified protein from bean seed, IAP1, is correlated to the developmental period of rapid growth during seed development. Moreover, this protein undergoes rapid degradation during germination. The gene for IAP1, the most abundant protein covalently modified by IAA (iap1, GenBank accession ... More
Mouse epididymal Spam1 (pH-20) is released in the luminal fluid with its lipid anchor.
AuthorsZhang H, Martin-Deleon PA,
JournalJ Androl
PubMed ID12514083
Previously we demonstrated that the murine sperm adhesion molecule 1 (Spam1 or PH-20) is synthesized by the epididymal epithelium, preferentially in the distal region, and is released into the luminal fluid. We also showed that whereas testicular and epididymal Spam1 have hyaluronidase activity at neutral pH, they are under different ... More
Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle.
AuthorsGoldammer T, Zerbe H, Molenaar A, Schuberth HJ, Brunner RM, Kata SR, Seyfert HM,
JournalClin Diagn Lab Immunol
PubMed ID14715566
Coordination of the primary defense mechanisms against pathogens relies on the appropriate expression of pathogen recognition receptors (PRRs) triggering the early release of effector molecules of the innate immune system. To analyze the impact of this system on the counteraction of infections of the mammary gland (mastitis), we characterized the ... More