'The purpose of the current study was to examine the binding of pulmonary surfactant protein A (SP-A) to TLR4 and MD-2, which are critical signaling receptors for lipopolysaccharides (LPSs). The direct binding of SP-A to the recombinant soluble form of extracellular TLR4 domain (sTLR4) and MD-2 was detected using solid-phase ... More
LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils.
AuthorsZhou X, Gao XP, Fan J, Liu Q, Anwar KN, Frey RS, Malik AB,
JournalAm J Physiol Lung Cell Mol Physiol
PubMed ID15563689
We identify herein a novel signaling function of the Toll-like receptor-4 (TLR4), the lipopolysaccharide (LPS) receptor mediating the innate immune response, in inducing the expression of CD11b/CD18 integrin in polymorphonuclear leukocytes (PMNs). Studies were made in PMNs isolated from TLR4-deficient (TLR4(-/-)) and C57BL/6 [wild-type (WT)] mice. We observed increased CD11b ... More
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway.
Innate immunity is an evolutionarily ancient system that provides organisms with immediately available defense mechanisms through recognition of pathogen-associated molecular patterns. We show that in the CNS, specific activation of innate immunity through a Toll-like receptor 4 (TLR4)-dependent pathway leads to neurodegeneration. We identify microglia as the major lipopolysaccharide (LPS)-responsive ... More
The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS.
The immediate or innate immune response is the first line of defense against diverse microbial pathogens and requires the expression of recently discovered toll-like receptors (TLRs). TLR4 serves as a specific receptor for lipopolysaccharide (LPS) and is localized on the surface of a subset of mammalian cells. Although innate immunity ... More
Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus.
AuthorsLoving CL, Brockmeier SL, Sacco RE
JournalImmunology
PubMed ID17116172
Dendritic cells (DCs) play a role in anti-viral immunity by providing early innate protection against viral replication and by presenting antigen to T cells for initiation of the adaptive immune response. Studies show the adaptive response to porcine reproductive and respiratory syndrome virus (PRRSV) is ineffective for complete viral elimination. ... More
Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide.
AuthorsOsterloh A, Kalinke U, Weiss S, Fleischer B, Breloer M
JournalJ Biol Chem
PubMed ID17164250
Activation of professional antigen-presenting cells (APC) is a crucial step in the initiation of an efficient immune response. In this study we show that Hsp60 mediates immune stimulation by different mechanisms, dependent and independent of lipopolysaccharide (LPS). We have demonstrated earlier that both, Hsp60 and LPS, increase antigen-specific interferon (IFN) ... More
Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity.
Authors
JournalEMBO Rep
PubMed ID33733573
Synthesis of the New Cyanine-Labeled Bacterial Lipooligosaccharides for Intracellular Imaging and in Vitro Microscopy Studies.
Authors
JournalBioconjug Chem
PubMed ID31136151
Mitoapocynin Attenuates Organic Dust Exposure-Induced Neuroinflammation and Sensory-Motor Deficits in a Mouse Model.
Authors
JournalFront Cell Neurosci
PubMed ID35496912
Enteric Glia Regulate Lymphocyte Activation via Autophagy-Mediated MHC-II Expression.
Authors
JournalCell Mol Gastroenterol Hepatol
PubMed ID34166814
Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock.
Authors
JournalEMBO Rep
PubMed ID33124745
Early glycolytic reprogramming controls microglial inflammatory activation.
Authors
JournalJ Neuroinflammation
PubMed ID34107997
BIG1 controls macrophage pro-inflammatory responses through ARF3-mediated PI(4,5)P2 synthesis.
Authors
JournalCell Death Dis
PubMed ID32415087
Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor.
Authors
JournalPLoS One
PubMed ID27171436
Advanced glycation end-products reduce lipopolysaccharide uptake by macrophages.
Authors
JournalPLoS One
PubMed ID33493233
Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.