Activation of proteinase-activated receptor-2 in mesothelial cells induces pleural inflammation.
AuthorsLee YC, Knight DA, Lane KB, Cheng DS, Koay MA, Teixeira LR, Nesbitt JC, Chambers RC, Thompson PJ, Light RW
JournalAm J Physiol Lung Cell Mol Physiol
PubMed ID15591415
'Pleural inflammation underlies many pleural diseases, but its pathogenesis remains unclear. Proteinase-activated receptor-2 (PAR(2)) is a novel seven-transmembrane receptor with immunoregulatory roles. We hypothesized that PAR(2) is present on mesothelial cells and can induce pleural inflammation. PAR(2) was detected by immunohistochemistry in all (19 parietal and 11 visceral) human pleural ... More
N-glycans of SREC-I (scavenger receptor expressed by endothelial cells): essential role for ligand binding, trafficking and stability.
AuthorsSano M, Korekane H, Ohtsubo K, Yamaguchi Y, Kato M, Shibukawa Y, Tajiri M, Adachi H, Wada Y, Asahi M, Taniguchi N,
JournalGlycobiology
PubMed ID22279061
'Scavenger receptor expressed by endothelial cells (SREC-I) mediates the endocytosis of chemically modified lipoproteins such as acetylated low-density lipoprotein (Ac-LDL) and oxidized LDL and is implicated in atherogenesis. We produced recombinant SREC-I in Chinese hamster ovary-K1 cells and identified three potential glycosylation sites, Asn(289), Asn(382) and Asn(393), which were all ... More
Uptake and trafficking of liposomes to the endoplasmic reticulum.
AuthorsPollock S, Antrobus R, Newton L, Kampa B, Rossa J, Latham S, Nichita NB, Dwek RA, Zitzmann N,
JournalFASEB J
PubMed ID20097877
'Liposomes are vesicular structures consisting of an aqueous core surrounded by a lipid bilayer. Apart from the cytosol and lysosomes, no other intracellular compartment has been successfully targeted using liposomal delivery. Here, we report the development of liposomes capable of specific targeting to the endoplasmic reticulum (ER) and associated membranes. ... More
Scavenger receptor classes A and B. Their roles in atherogenesis and the metabolism of modified LDL and HDL.
AuthorsVan Berkel TJ, Van Eck M, Herijgers N, Fluiter K, Nion S
JournalAnn N Y Acad Sci
PubMed ID10865831
'Scavenger-receptor class A has been held responsible for the clearance of modified LDL from the blood circulation. However, in mice deficient in scavenger-receptor class A, the decay in vivo of acetylated LDL (t1/2 < 2 min), as well as tissue distribution and liver uptake (at 5 min 77.4 +/- 4.6% ... More
Role of phospholipid transfer protein in high-density lipoprotein metabolism: insights from studies in transgenic mice.
AuthorsVan Tol A, Jauhiainen M, De Crom R, Ehnholm C
JournalInt J Tissue React
PubMed ID10937357
The role of oxidized low-density lipoproteins in the pathogenesis of atherosclerosis.
AuthorsParthasarathy S, Steinberg D, Witztum JL
JournalAnnu Rev Med
PubMed ID1580586
Hypercholesterolemia is a major risk for atherogenesis. Recent evidence suggests that oxidative modification of the major cholesterol-carrying lipoprotein, low-density lipoprotein (LDL), renders it more atherogenic. Not only does oxidized LDL (Ox-LDL) have enhanced uptake by macrophages, which contributes directly to foam cell formation, it may also adversely affect many other ... More
LXRa is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.
AuthorsHong C, Bradley MN, Rong X, Wang X, Wagner A, Grijalva V, Castellani LW, Salazar J, Realegeno S, Boyadjian R, Fogelman AM, Van Lenten BJ, Reddy ST, Lusis AJ, Tangirala RK, Tontonoz P,
JournalJ Lipid Res
PubMed ID22454476
The liver X receptor (LXR) signaling pathway is an important modulator of atherosclerosis, but the relative importance of the two LXRs in atheroprotection is incompletely understood. We show here that LXRa, the dominant LXR isotype expressed in liver, plays a particularly important role in whole-body sterol homeostasis. In the context ... More
FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.
AuthorsBlom T, Bäck N, Mutka AL, Bittman R, Li Z, de Lera A, Kovanen PT, Diczfalusy U, Ikonen E,
JournalCirc Res
PubMed ID20056921
The synthetic sphingosine analog FTY720 is undergoing clinical trials as an immunomodulatory compound, acting primarily via sphingosine 1-phosphate receptor activation. Sphingolipid and cholesterol homeostasis are closely connected but whether FTY720 affects atherogenesis in humans is not known. We examined the effects of FTY720 on the processing of scavenged lipoprotein cholesterol ... More
Scavenger receptors that recognize advanced glycation end products.
AuthorsMiyazaki A, Nakayama H, Horiuchi S
JournalTrends Cardiovasc Med
PubMed ID12242049
Scavenger receptors recognize modified low-density lipoproteins (LDLs) such as acetylated LDL and oxidized LDL. Advanced glycation end products (AGE), which are generated through long-term exposure of proteins to glucose, also behave as active ligands for some scavenger receptors, including class A scavenger receptor (SR-A) and class B scavenger receptors such ... More
Roles of lectin-like oxidized LDL receptor-1 and its soluble forms in atherogenesis.
AuthorsKume N, Kita T
JournalCurr Opin Lipidol
PubMed ID11507327
Lectin-like oxidized LDL receptor (LOX)-1 is a type II membrane protein that belongs to the C-type lectin family of molecules, which can act as a cell-surface endocytosis receptor for atherogenic oxidized LDL. LOX-1 can support binding, internalization and proteolytic degradation of oxidized LDL, but not of significant amounts of acetylated ... More
Endothelium-derived vasoactive mediators and renal glomerular function.
AuthorsBallermann BJ, Marsden PA
JournalClin Invest Med
PubMed ID1794204
Glomerular endothelial cells are located in extremely close proximity to glomerular mesangial cells, without intervening basement membrane. This close apposition of the two cell types suggest that interactions between the cells should readily occur. Given that endothelial cells are known to produce mediators which regulate the tone of underlying vascular ... More
Facile Cholesterol Loading with a New Probe ezFlux Allows for Streamlined Cholesterol Efflux Assays.
Authors
JournalACS Omega
PubMed ID32954180
Aortic Gene Expression Profiles Show How ApoA-I Levels Modulate Inflammation, Lysosomal Activity, and Sphingolipid Metabolism in Murine Atherosclerosis.
Authors
JournalArterioscler Thromb Vasc Biol
PubMed ID33327742
Apolipoprotein E derived from CD11c+ cells ameliorates atherosclerosis.
Authors
JournaliScience
PubMed ID35036868
Circulating mouse Flk1+/c-Kit+/CD45- cells function as endothelial progenitors cells (EPCs) and stimulate the growth of human tumor xenografts.
Authors
JournalMol Cancer
PubMed ID25047738
Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial.
Authors
JournalClin Cancer Res
PubMed ID34078651
Novel Insights Into Sterol Uptake and Intracellular Cholesterol Trafficking During Eimeria bovis Macromeront Formation.