Proteasome inhibitors reduce luciferase and beta-galactosidase activity in tissue culture cells.
Authors Deroo Bonnie J; Archer Trevor K;
JournalJ Biol Chem
PubMed ID11959849
Reporter enzymes are commonly used in cell biology to study transcriptional activity of genes. Recently, reporter enzymes in combination with compounds that inhibit proteasome function have been used to study the effect of blocking transcription factor degradation on gene activation. While investigating the effect of proteasome inhibition on steroid receptor ... More